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Interleukin-10 in Health and Disease

Overview of attention for book
Cover of 'Interleukin-10 in Health and Disease'

Table of Contents

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    Book Overview
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    Chapter 1 IL-10 in Humans: Lessons from the Gut, IL-10/IL-10 Receptor Deficiencies, and IL-10 Polymorphisms.
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    Chapter 2 Control of intestinal inflammation by interleukin-10.
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    Chapter 3 Tr1 cells and the counter-regulation of immunity: natural mechanisms and therapeutic applications.
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    Chapter 4 Interleukin-10-producing B cells and the regulation of immunity.
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    Chapter 5 Pathogen Manipulation of cIL-10 Signaling Pathways: Opportunities for Vaccine Development?
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    Chapter 6 IL-10: Achieving Balance During Persistent Viral Infection
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    Chapter 7 The Role of microRNAs in the Control and Mechanism of Action of IL-10
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    Chapter 8 The regulation of IL-10 expression.
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    Chapter 9 The Molecular Basis of IL-10 Function: from Receptor Structure to the Onset of Signaling
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    Chapter 10 Role of IL-22 in Microbial Host Defense.
Attention for Chapter 8: The regulation of IL-10 expression.
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Citations

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Chapter title
The regulation of IL-10 expression.
Chapter number 8
Book title
Interleukin-10 in Health and Disease
Published in
Current topics in microbiology and immunology, January 2014
DOI 10.1007/978-3-662-43492-5_8
Pubmed ID
25004818
Book ISBNs
978-3-66-243491-8, 978-3-66-243492-5
Authors

Leona Gabryšová, Ashleigh Howes, Margarida Saraiva, Anne O'Garra, Anne O’Garra, Gabryšová, Leona, Howes, Ashleigh, Saraiva, Margarida, O’Garra, Anne

Abstract

Interleukin (IL)-10 is an important immunoregulatory cytokine and an understanding of how IL-10 expression is controlled is critical in the design of immune intervention strategies. IL-10 is produced by almost all cell types within the innate (including macrophages, monocytes, dendritic cells (DCs), mast cells, neutrophils, eosinophils and natural killer cells) and adaptive (including CD4(+) T cells, CD8(+) T cells and B cells) immune systems. The mechanisms of IL-10 regulation operate at several stages including chromatin remodelling at the Il10 locus, transcriptional regulation of Il10 expression and post-transcriptional regulation of Il10 mRNA. In addition, whereas some aspects of Il10 gene regulation are conserved between different immune cell types, several are cell type- or stimulus-specific. Here, we outline the complexity of IL-10 production by discussing what is known about its regulation in macrophages, monocytes, DCs and CD4(+) T helper cells.

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X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 118 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 118 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 17%
Student > Bachelor 18 15%
Researcher 16 14%
Student > Master 12 10%
Student > Doctoral Student 8 7%
Other 14 12%
Unknown 30 25%
Readers by discipline Count As %
Agricultural and Biological Sciences 20 17%
Immunology and Microbiology 20 17%
Biochemistry, Genetics and Molecular Biology 17 14%
Medicine and Dentistry 13 11%
Neuroscience 6 5%
Other 12 10%
Unknown 30 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 November 2014.
All research outputs
#14,197,510
of 22,758,248 outputs
Outputs from Current topics in microbiology and immunology
#391
of 671 outputs
Outputs of similar age
#173,659
of 305,266 outputs
Outputs of similar age from Current topics in microbiology and immunology
#9
of 14 outputs
Altmetric has tracked 22,758,248 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 671 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 305,266 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.

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