| Chapter title |
Host Detection and the Stealthy Phenotype in Influenza Virus Infection.
|
|---|---|
| Chapter number | 412 |
| Book title |
Influenza Pathogenesis and Control - Volume II
|
| Published in |
Current topics in microbiology and immunology, July 2014
|
| DOI | 10.1007/82_2014_412 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-911157-5, 978-3-31-911158-2
|
| Authors |
Dash P, Thomas PG, Pradyot Dash, Paul G. Thomas |
| Abstract |
The innate host response to influenza virus infection plays a critical role in determining the subsequent course of infection and the clinical outcome of disease. The host has a diverse array of detection and effector mechanisms that are able to recognize and initiate effective antiviral responses. In opposition, the virus utilizes a number of distinct mechanisms to evade host detection and effector activity in order to remain "stealthy" throughout its replication cycle. In this review, we describe these host and viral mechanisms, including the major pattern recognition receptor families (the TLRs, NLRs, and RLRs) in the host and the specific viral proteins such as NS1 that are key players in this interaction. Additionally, we explore nonreductive mechanisms of viral immune evasion and propose areas important for future inquiry. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Belgium | 1 | 4% |
| Unknown | 22 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 5 | 22% |
| Student > Ph. D. Student | 4 | 17% |
| Researcher | 3 | 13% |
| Student > Bachelor | 2 | 9% |
| Lecturer | 2 | 9% |
| Other | 4 | 17% |
| Unknown | 3 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 7 | 30% |
| Medicine and Dentistry | 4 | 17% |
| Immunology and Microbiology | 4 | 17% |
| Veterinary Science and Veterinary Medicine | 1 | 4% |
| Biochemistry, Genetics and Molecular Biology | 1 | 4% |
| Other | 2 | 9% |
| Unknown | 4 | 17% |