Chapter title |
Genetic and Epigenetic Control of Early Lymphocyte Development.
|
---|---|
Chapter number | 370 |
Book title |
Transcriptional Control of Lineage Differentiation in Immune Cells
|
Published in |
Current topics in microbiology and immunology, May 2014
|
DOI | 10.1007/82_2014_370 |
Pubmed ID | |
Book ISBNs |
978-3-31-907394-1, 978-3-31-907395-8
|
Authors |
Tomokatsu Ikawa |
Editors |
Wilfried Ellmeier, Ichiro Taniuchi |
Abstract |
T, B, and NK lymphocytes are generated from pluripotent hematopoietic stem cells through a successive series of lineage restriction processes. Many regulatory components, such as transcription factors, cytokines/cytokine receptors, and signal transduction molecules orchestrate cell fate specification and determination. In particular, transcription factors play a key role in regulating lineage-associated gene programs. Recent findings suggest the involvement of epigenetic factors in the maintenance of cell fate. Here, we review the early developmental events during lymphocyte lineage determination, focusing on the transcriptional networks and epigenetic regulation. Finally, we also discuss the developmental relationship between acquired and innate lymphoid cells. |
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