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PARP Inhibitors for Cancer Therapy

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Cover of 'PARP Inhibitors for Cancer Therapy'

Table of Contents

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    Book Overview
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    Chapter 1 History of the Discovery of Poly (ADP-ribose)
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    Chapter 2 Discovery of the PARP Superfamily and Focus on the Lesser Exhibited But Not Lesser Talented Members
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    Chapter 3 The Role of PARPs in DNA Strand Break Repair
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    Chapter 4 TIPs: Tankyrase Interacting Proteins
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    Chapter 5 PARP and Carcinogenesis
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    Chapter 6 Multitasking Roles for Poly(ADP-ribosyl)ation in Aging and Longevity
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    Chapter 7 Overview of PARP Inhibitor Design and Optimization
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    Chapter 8 Structure Based Design of PARP Inhibitors
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    Chapter 9 Preclinical Chemosensitization by PARP Inhibitors
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    Chapter 10 Classification of PARP Inhibitors Based on PARP Trapping and Catalytic Inhibition, and Rationale for Combinations with Topoisomerase I Inhibitors and Alkylating Agents
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    Chapter 11 Radiosensitisation by Poly(ADP-ribose) Polymerase Inhibition
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    Chapter 12 The Vasoactivity of PARP Inhibitors
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    Chapter 13 PARP Inhibitors for Cancer Therapy
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    Chapter 14 Targeting Tumour Hypoxia with PARP Inhibitors: Contextual Synthetic Lethality
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    Chapter 15 Other Determinants of Sensitivity
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    Chapter 16 Synthetic Sickness with Molecularly Targeted Agents Against the EGFR Pathway
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    Chapter 17 Disruption of DNA Repair by Cell Cycle and Transcriptional CDK Inhibition
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    Chapter 18 Resistance to PARP Inhibitors Mediated by Secondary BRCA1/2 Mutations
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    Chapter 19 PARP Inhibitor Resistance—What Is Beyond BRCA1 or BRCA2 Restoration?
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    Chapter 20 Introduction to PARPi Clinical Trials and Future Directions
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    Chapter 21 Clinical Trials Investigating PARP Inhibitors as Single Agents
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    Chapter 22 Clinical Trials of PARP Inhibitors with Chemotherapy
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    Chapter 23 Combination of PARP Inhibitors with Clinical Radiotherapy
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    Chapter 24 Biomarkers for PARP Inhibitors
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2 Wikipedia pages

Citations

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Title
PARP Inhibitors for Cancer Therapy
Published by
Springer International Publishing, January 2015
DOI 10.1007/978-3-319-14151-0
ISBNs
978-3-31-914150-3, 978-3-31-914151-0
Editors

Nicola J. Curtin, Ricky A. Sharma

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 1 Mendeley reader of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 1 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 2 200%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 2 200%

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