Chapter title |
Tumor Oxygenation Status: Facts and Fallacies
|
---|---|
Chapter number | 13 |
Book title |
Oxygen Transport to Tissue XXXIX
|
Published in |
Advances in experimental medicine and biology, July 2017
|
DOI | 10.1007/978-3-319-55231-6_13 |
Pubmed ID | |
Book ISBNs |
978-3-31-955229-3, 978-3-31-955231-6
|
Authors |
Peter Vaupel, Arnulf Mayer |
Abstract |
In this chapter we allude to a series of facts and fallacies often encountered in the description of tumor hypoxia, a relevant trait of the tumor microenvironment and a paramount driver of tumor aggressiveness and treatment resistance. The critical role of diffusion distances, terminological inconsistencies considering O2 partial pressures vs. O2 concentrations and with it the use of inept units, the impact of O2 depletion on proliferation and cell viability, the switch in the Warburg dogma , the distribution of hypoxic subvolumes within a tumor, the involvement of O2 diffusion shunts in the development of chronic hypoxia, and the role of endogenous biomarkers as surrogates for the assessment of hypoxia are discussed in more detail. Special emphasis is put on the clinical relevance of these misconceptions and misinterpretations and their impact on the assessment of hypoxia as well as hypoxia-targeted treatment planning. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 13 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 2 | 15% |
Student > Ph. D. Student | 2 | 15% |
Unspecified | 1 | 8% |
Student > Bachelor | 1 | 8% |
Professor | 1 | 8% |
Other | 3 | 23% |
Unknown | 3 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Veterinary Science and Veterinary Medicine | 2 | 15% |
Biochemistry, Genetics and Molecular Biology | 2 | 15% |
Medicine and Dentistry | 2 | 15% |
Unspecified | 1 | 8% |
Agricultural and Biological Sciences | 1 | 8% |
Other | 3 | 23% |
Unknown | 2 | 15% |