Chapter title |
Cyclin B in mouse oocytes and embryos: importance for human reproduction and aneuploidy.
|
---|---|
Chapter number | 4 |
Book title |
Mouse Development
|
Published in |
Results and problems in cell differentiation, January 2012
|
DOI | 10.1007/978-3-642-30406-4-4 |
Pubmed ID | |
Book ISBNs |
978-3-64-230405-7, 978-3-64-230406-4
|
Authors |
Polański, Zbigniew, Homer, Hayden, Kubiak, Jacek Z, Zbigniew Polański, Hayden Homer, Jacek Z. Kubiak |
Editors |
Jacek Z. Kubiak |
Abstract |
Oocyte maturation and early embryo development require precise coordination between cell cycle progression and the developmental programme. Cyclin B plays a major role in this process: its accumulation and degradation is critical for driving the cell cycle through activation and inactivation of the major cell cycle kinase, CDK1. CDK1 activation is required for M-phase entry whereas its inactivation leads to exit from M-phase. The tempo of oocyte meiotic and embryonic mitotic divisions is set by the rate of cyclin B accumulation and the timing of its destruction. By controlling when cyclin B destruction is triggered and by co-ordinating this with the completion of chromosome alignment, the spindle assembly checkpoint (SAC) is a critical quality control system important for averting aneuploidy and for building in the flexibility required to better integrate cell cycle progression with development. In this review we focus on cyclin B metabolism in mouse oocytes and embryos and illustrate how the cell cycle-powered clock (in fact cyclin B-powered clock) controls oocyte maturation and early embryo development, thereby providing important insight into human reproduction and potential causes of Down syndrome. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 6 | 600% |
Student > Ph. D. Student | 3 | 300% |
Student > Bachelor | 2 | 200% |
Student > Doctoral Student | 1 | 100% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 5 | 500% |
Biochemistry, Genetics and Molecular Biology | 3 | 300% |
Medicine and Dentistry | 2 | 200% |
Immunology and Microbiology | 1 | 100% |