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Malaria Vaccines

Overview of attention for book
Cover of 'Malaria Vaccines'

Table of Contents

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    Book Overview
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    Chapter 1 Isolation of Non-parenchymal Cells from the Mouse Liver.
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    Chapter 2 Measurement of the T Cell Response to Preerythrocytic Vaccination in Mice.
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    Chapter 3 Characterization of Liver CD8 T Cell Subsets that are Associated with Protection Against Pre-erythrocytic Plasmodium Parasites.
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    Chapter 4 Flow Cytometry-Based Assessment of Antibody Function Against Malaria Pre-erythrocytic Infection.
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    Chapter 5 Assessment of Parasite Liver-Stage Burden in Human-Liver Chimeric Mice
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    Chapter 6 Measurement of Antibody-Mediated Reduction of Plasmodium yoelii Liver Burden by Bioluminescent Imaging.
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    Chapter 7 Detection of Plasmodium berghei and Plasmodium yoelii Liver-Stage Parasite Burden by Quantitative Real-Time PCR.
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    Chapter 8 Membrane Feeding Assay to Determine the Infectiousness of Plasmodium vivax Gametocytes.
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    Chapter 9 The Standard Membrane Feeding Assay: Advances Using Bioluminescence.
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    Chapter 10 Agglutination Assays of the Plasmodium falciparum-Infected Erythrocyte.
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    Chapter 11 Antibody-Dependent Cell-Mediated Inhibition (ADCI) of Plasmodium falciparum: One- and Two-Step ADCI Assays.
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    Chapter 12 A Robust Phagocytosis Assay to Evaluate the Opsonic Activity of Antibodies against Plasmodium falciparum-Infected Erythrocytes.
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    Chapter 13 Miniaturized Growth Inhibition Assay to Assess the Anti-blood Stage Activity of Antibodies.
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    Chapter 14 Measuring Plasmodium falciparum Erythrocyte Invasion Phenotypes Using Flow Cytometry.
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    Chapter 15 The In Vitro Invasion Inhibition Assay (IIA) for Plasmodium vivax.
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    Chapter 16 The Ex Vivo IFN-γ Enzyme-Linked Immunospot (ELISpot) Assay.
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    Chapter 17 Evaluating IgG Antibody to Variant Surface Antigens Expressed on Plasmodium falciparum Infected Erythrocytes Using Flow Cytometry.
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    Chapter 18 Inhibition of Infected Red Blood Cell Binding to the Vascular Endothelium.
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    Chapter 19 Evaluation of Pregnancy Malaria Vaccine Candidates: The Binding Inhibition Assay.
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    Chapter 20 High-Throughput Testing of Antibody-Dependent Binding Inhibition of Placental Malaria Parasites.
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    Chapter 21 Generation of Transgenic Rodent Malaria Parasites Expressing Human Malaria Parasite Proteins.
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    Chapter 22 Vaccination Using Gene-Gun Technology.
Attention for Chapter 5: Assessment of Parasite Liver-Stage Burden in Human-Liver Chimeric Mice
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Chapter title
Assessment of Parasite Liver-Stage Burden in Human-Liver Chimeric Mice
Chapter number 5
Book title
Malaria Vaccines
Published in
Methods in molecular biology, January 2015
DOI 10.1007/978-1-4939-2815-6_5
Pubmed ID
26450379
Book ISBNs
978-1-4939-2814-9, 978-1-4939-2815-6
Authors

Lander Foquet, Philip Meuleman, Cornelus C. Hermsen, Robert Sauerwein, Geert Leroux-Roels

Editors

Ashley Vaughan

Abstract

Humanized mice with a chimeric liver are a promising tool to evaluate the "in vivo" efficacy of novel compounds or vaccine-induced antibodies directed against the pre-erythrocytic stages of Plasmodium falciparum. The absence of human red blood cells in these humanized mice precludes the transition from liver to blood stage. The qPCR-based method described below allows for a sensitive and reliable quantification of parasite DNA in the chimeric liver following a challenge via infected mosquito bite or intravenous injection of sporozoites. With this method approximately 25 % of the total chimeric liver is examined and a single infected hepatocyte can be detected in the analyzed tissue. The use of appropriate species-specific probes can also allow for the detection of other Plasmodium species in vivo.

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X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 2 25%
Student > Master 2 25%
Professor 1 13%
Student > Bachelor 1 13%
Student > Ph. D. Student 1 13%
Other 1 13%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 1 13%
Nursing and Health Professions 1 13%
Agricultural and Biological Sciences 1 13%
Computer Science 1 13%
Immunology and Microbiology 1 13%
Other 3 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 October 2015.
All research outputs
#18,556,449
of 22,982,639 outputs
Outputs from Methods in molecular biology
#7,946
of 13,149 outputs
Outputs of similar age
#257,039
of 354,122 outputs
Outputs of similar age from Methods in molecular biology
#484
of 998 outputs
Altmetric has tracked 22,982,639 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,149 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 354,122 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 998 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.

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