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Germinal Centers

Overview of attention for book
Cover of 'Germinal Centers'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Analysis of the Germinal Center Reaction in Tissue Sections
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    Chapter 2 Detecting Gene Expression in Lymphoid Microenvironments by Laser Microdissection and Quantitative RT-PCR
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    Chapter 3 Tracking Plasma Cell Differentiation in Living Mice with Two-Photon Microscopy
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    Chapter 4 Microanatomical Labeling of Germinal Center Structures for Flow Cytometry Using Photoactivation
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    Chapter 5 Fate Mapping and Transcript Profiling of Germinal Center Cells by Two-Photon Photoconversion
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    Chapter 6 Intravital Microscopy of T–B Cell Interactions in Germinal Centers
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    Chapter 7 Identifying Follicular Regulatory T Cells by Confocal Microscopy
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    Chapter 8 Cytokine Expression by T Follicular Helper Cells
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    Chapter 9 Follicular Dendritic Cell Isolation and Loading of Immune Complexes
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    Chapter 10 Isolation and Characterization of Mouse and Human Follicular Dendritic Cells
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    Chapter 11 In Vitro-Induced Germinal Center B Cell Culture System
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    Chapter 12 CRISPR/Cas9-Mediated In Vitro Mutagenesis in GC-Like B Cells
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    Chapter 13 Germinal Center Formation with Retrovirally Transduced B Cells for Determining the Role of Specific Molecules In Vivo
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    Chapter 14 Characterization of the B Cell Transcriptome Bound by RNA-Binding Proteins with iCLIP
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    Chapter 15 Flow-Cytometric Method Measuring B Cell Surface Immunoglobulin Avidity
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    Chapter 16 Somatic Hypermutation and Affinity Maturation Analysis Using the 4-Hydroxy-3-Nitrophenyl-Acetyl (NP) System
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    Chapter 17 Targeting Gene Function in Germinal Center B Cells: A Practical Approach
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    Chapter 18 Development of Mouse Model Systems of Germinal Center Lymphomas
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    Chapter 19 The AID-Cre-ERT2 Model: A Tool for Monitoring B Cell Immune Responses and Generating Selective Hybridomas
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    Chapter 20 Determining the Origin of Human Germinal Center B Cell-Derived Malignancies
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    Chapter 21 Tracking B-Cell Repertoires and Clonal Histories in Normal and Malignant Lymphocytes
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    Chapter 22 How to Simulate a Germinal Center
Attention for Chapter 14: Characterization of the B Cell Transcriptome Bound by RNA-Binding Proteins with iCLIP
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Chapter title
Characterization of the B Cell Transcriptome Bound by RNA-Binding Proteins with iCLIP
Chapter number 14
Book title
Germinal Centers
Published in
Methods in molecular biology, June 2017
DOI 10.1007/978-1-4939-7095-7_14
Pubmed ID
28589356
Book ISBNs
978-1-4939-7094-0, 978-1-4939-7095-7
Authors

Díaz-Muñoz, Manuel D., Monzón-Casanova, Elisa, Turner, Martin, Manuel D. Díaz-Muñoz, Elisa Monzón-Casanova, Martin Turner

Abstract

Posttranscriptional regulation of gene expression shapes the B cell transcriptome and controls messenger RNA (mRNA) translation into protein. Recent reports have highlighted the importance of RNA binding proteins (RBPs) for mRNA splicing, subcellular location, stability, and translation during B lymphocyte development, activation, and differentiation. Here we describe individual-nucleotide resolution UV cross-linking and immunoprecipitation (iCLIP) in primary lymphocytes, a method that maps RNA-protein interactions in a genome-wide scale allowing mechanistic analysis of RBP function. We discuss the latest improvements in iCLIP technology and provide some examples of how integration of the RNA-protein interactome with other high-throughput mRNA sequencing methodologies uncovers the important role of RBP-mediated RNA regulation in key biological cell processes.

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X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 38%
Student > Bachelor 2 25%
Professor 1 13%
Other 1 13%
Unknown 1 13%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 2 25%
Agricultural and Biological Sciences 2 25%
Computer Science 1 13%
Immunology and Microbiology 1 13%
Unknown 2 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 June 2017.
All research outputs
#15,464,404
of 22,979,862 outputs
Outputs from Methods in molecular biology
#5,379
of 13,147 outputs
Outputs of similar age
#199,222
of 317,348 outputs
Outputs of similar age from Methods in molecular biology
#111
of 304 outputs
Altmetric has tracked 22,979,862 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,147 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,348 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 304 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.

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