Chapter title |
Retroviral Vectors for Cancer Gene Therapy
|
---|---|
Chapter number | 2 |
Book title |
Current Strategies in Cancer Gene Therapy
|
Published in |
Recent results in cancer research Fortschritte der Krebsforschung Progrès dans les recherches sur le cancer, January 2016
|
DOI | 10.1007/978-3-319-42934-2_2 |
Pubmed ID | |
Book ISBNs |
978-3-31-942932-8, 978-3-31-942934-2, 978-3-31-942932-8, 978-3-31-942934-2
|
Authors |
Axel Schambach, Michael Morgan, Schambach, Axel, Morgan, Michael |
Abstract |
Advances in molecular technologies have led to the discovery of many disease-related genetic mutations as well as elucidation of aberrant gene and protein expression patterns in several human diseases, including cancer. This information has driven the development of novel therapeutic strategies, such as the utilization of small molecules to target specific cellular pathways and the use of retroviral vectors to retarget immune cells to recognize and eliminate tumor cells. Retroviral-mediated gene transfer has allowed efficient production of T cells engineered with chimeric antigen receptors (CARs), which have demonstrated marked success in the treatment of hematological malignancies. As a safety point, these modified cells can be outfitted with suicide genes. Customized gene editing tools, such as clustered regularly interspaced short palindromic repeats-CRISPR-associated nucleases (CRISPR-Cas9), zinc-finger nucleases (ZFNs), or TAL-effector nucleases (TALENs), may also be combined with retroviral delivery to specifically delete oncogenes, inactivate oncogenic signaling pathways, or deliver wild-type genes. Additionally, the feasibility of retroviral gene transfer strategies to protect the hematopoietic stem cells (HSC) from the dose-limiting toxic effects of chemotherapy and radiotherapy was demonstrated. While some of these approaches have yet to be translated into clinical application, the potential implications for improved cellular replacement therapies to enhance and/or support the current treatment modalities are enormous. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 20% |
Unknown | 4 | 80% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 66 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 11 | 17% |
Researcher | 9 | 14% |
Student > Bachelor | 8 | 12% |
Other | 6 | 9% |
Student > Master | 6 | 9% |
Other | 7 | 11% |
Unknown | 19 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 14 | 21% |
Medicine and Dentistry | 10 | 15% |
Agricultural and Biological Sciences | 7 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
Engineering | 2 | 3% |
Other | 6 | 9% |
Unknown | 24 | 36% |