Chapter title |
Functional Role of Nox4 in Autophagy.
|
---|---|
Chapter number | 16 |
Book title |
Mitochondrial Dynamics in Cardiovascular Medicine
|
Published in |
Advances in experimental medicine and biology, May 2017
|
DOI | 10.1007/978-3-319-55330-6_16 |
Pubmed ID | |
Book ISBNs |
978-3-31-955329-0, 978-3-31-955330-6
|
Authors |
Forte, Maurizio, Palmerio, Silvia, Yee, Derek, Frati, Giacomo, Sciarretta, Sebastiano, Maurizio Forte PhD, Silvia Palmerio MS, Derek Yee MD, Giacomo Frati MD, Sebastiano Sciarretta MD, PhD, Maurizio Forte, Silvia Palmerio, Derek Yee, Giacomo Frati, Sebastiano Sciarretta |
Editors |
Gaetano Santulli |
Abstract |
Accumulating lines of evidence suggest that reactive oxygen species (ROS) may act as intracellular signaling molecules under cellular stress conditions, activating several molecular pathways. Autophagy, the intracellular mechanism by which cells digest and recycle unfolded proteins and dysfunctional organelles, is emerging as a major target of ROS and NADPH oxidase (Nox) enzymes, the major generators of ROS. While autophagy represents an important self-defense mechanism in promoting cell survival, it may be maladaptive in some conditions. In particular, in the cardiovascular system, moderate activation of autophagy has been shown to be protective, while excessive or insufficient activation of autophagy may be deleterious. Thus, modulating ROS-dependent autophagy may represent a novel strategy to keep autophagy within the therapeutic range. Among the Nox isoforms, Nox4 in particular plays a pivotal role in autophagy regulation. This appears to be due to its intracellular localization and its ability to produce hydrogen peroxide, a stable signaling molecule. In this chapter we review the studies relating to the functional role of Nox4 in autophagy, with particular emphasis on the heart and cardiovascular system. |
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Researcher | 2 | 12% |
Professor | 1 | 6% |
Student > Bachelor | 1 | 6% |
Professor > Associate Professor | 1 | 6% |
Other | 1 | 6% |
Unknown | 7 | 41% |
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Chemical Engineering | 2 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
Agricultural and Biological Sciences | 1 | 6% |
Medicine and Dentistry | 1 | 6% |
Other | 1 | 6% |
Unknown | 8 | 47% |