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Mitochondrial Dynamics in Cardiovascular Medicine

Overview of attention for book
Cover of 'Mitochondrial Dynamics in Cardiovascular Medicine'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Functional Implications of Cardiac Mitochondria Clustering
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    Chapter 2 Mitochondrial Calcium Handling in Physiology and Disease
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    Chapter 3 The In Vivo Biology of the Mitochondrial Calcium Uniporter
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    Chapter 4 Mitochondrial Bioenergetics and Dysfunction in Failing Heart
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    Chapter 5 Mitochondrial Mutations in Cardiac Disorders.
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    Chapter 6 Mitochondrial Function in Non-ischemic Heart Failure
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    Chapter 7 Mitochondria in Ischemic Heart Disease
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    Chapter 8 Mitochondrial Bioenergetics During Ischemia and Reperfusion.
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    Chapter 9 Mechanistic Role of mPTP in Ischemia-Reperfusion Injury
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    Chapter 10 Functional Role of Mitochondria in Arrhythmogenesis
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    Chapter 11 Mitochondria and Cardiac Hypertrophy
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    Chapter 12 Connexin 43 and Mitochondria in Cardiovascular Health and Disease
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    Chapter 13 Mitochondrial Mechanosensor Microdomains in Cardiovascular Disorders
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    Chapter 14 Mechanistic Role of Thioredoxin 2 in Heart Failure
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    Chapter 15 Mitochondria in Structural and Functional Cardiac Remodeling.
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    Chapter 16 Functional Role of Nox4 in Autophagy.
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    Chapter 17 Mitochondrial Ubiquitin Ligase in Cardiovascular Disorders
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    Chapter 18 Nitrite-Nitric Oxide Signaling and Cardioprotection
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    Chapter 19 Peripheral Blood Mitochondrial DNA and Myocardial Function
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    Chapter 20 Mitochondrial Proton Leak Plays a Critical Role in Pathogenesis of Cardiovascular Diseases
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    Chapter 21 Mitochondria and Angiogenesis
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    Chapter 22 High-Density Lipoprotein Regulation of Mitochondrial Function
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    Chapter 23 MitomiRs Keep the Heart Beating.
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    Chapter 24 Mitochondrial Dysfunction in Cardiovascular Aging
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    Chapter 25 Insulin Resistance and Mitochondrial Dysfunction
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    Chapter 26 Mechanistic Role of Kinases in the Regulation of Mitochondrial Fitness
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    Chapter 27 Mitochondria Damage and Kidney Disease
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    Chapter 28 Mitochondrial Dysfunction in the Diabetic Kidney
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    Chapter 29 Prohibitin Signaling at the Kidney Filtration Barrier
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    Chapter 30 Mitochondrial Heteroplasmy
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    Chapter 31 Mitochondrial Transplantation in Myocardial Ischemia and Reperfusion Injury
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    Chapter 32 Mitochondria-Targeted Antioxidants for the Treatment of Cardiovascular Disorders
Attention for Chapter 25: Insulin Resistance and Mitochondrial Dysfunction
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

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Citations

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26 Dimensions

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129 Mendeley
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1 CiteULike
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Chapter title
Insulin Resistance and Mitochondrial Dysfunction
Chapter number 25
Book title
Mitochondrial Dynamics in Cardiovascular Medicine
Published in
Advances in experimental medicine and biology, May 2017
DOI 10.1007/978-3-319-55330-6_25
Pubmed ID
Book ISBNs
978-3-31-955329-0, 978-3-31-955330-6
Authors

Gonzalez-Franquesa, Alba, Patti, Mary-Elizabeth, Alba Gonzalez-Franquesa, Mary-Elizabeth Patti

Editors

Gaetano Santulli

Abstract

Insulin resistance precedes and predicts the onset of type 2 diabetes (T2D) in susceptible humans, underscoring its important role in the complex pathogenesis of this disease. Insulin resistance contributes to multiple tissue defects characteristic of T2D, including reduced insulin-stimulated glucose uptake in insulin-sensitive tissues, increased hepatic glucose production, increased lipolysis in adipose tissue, and altered insulin secretion. Studies of individuals with insulin resistance, both with established T2D and high-risk individuals, have consistently demonstrated a diverse array of defects in mitochondrial function (i.e., bioenergetics, biogenesis and dynamics). However, it remains uncertain whether mitochondrial dysfunction is primary (critical initiating defect) or secondary to the subtle derangements in glucose metabolism, insulin resistance, and defective insulin secretion present early in the course of disease development. In this chapter, we will present the evidence linking mitochondrial dysfunction and insulin resistance, and review the potential for mitochondrial targets as a therapeutic approach for T2D.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 129 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Malaysia 1 <1%
Unknown 128 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 21 16%
Student > Bachelor 19 15%
Researcher 14 11%
Student > Ph. D. Student 14 11%
Student > Doctoral Student 5 4%
Other 14 11%
Unknown 42 33%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 22 17%
Medicine and Dentistry 18 14%
Pharmacology, Toxicology and Pharmaceutical Science 8 6%
Agricultural and Biological Sciences 7 5%
Immunology and Microbiology 5 4%
Other 22 17%
Unknown 47 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 December 2017.
All research outputs
#1,745,068
of 22,977,819 outputs
Outputs from Advances in experimental medicine and biology
#230
of 4,957 outputs
Outputs of similar age
#35,869
of 313,536 outputs
Outputs of similar age from Advances in experimental medicine and biology
#9
of 125 outputs
Altmetric has tracked 22,977,819 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,957 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,536 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 125 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.