Title |
Detecting a single molecule using a micropore-nanopore hybrid chip
|
---|---|
Published in |
Discover Nano, November 2013
|
DOI | 10.1186/1556-276x-8-498 |
Pubmed ID | |
Authors |
Lei Liu, Lizhong Zhu, Zhonghua Ni, Yunfei Chen |
Abstract |
Nanopore-based DNA sequencing and biomolecule sensing have attracted more and more attention. In this work, novel sensing devices were built on the basis of the chips containing nanopore arrays in polycarbonate (PC) membranes and micropores in Si3N4 films. Using the integrated chips, the transmembrane ionic current induced by biomolecule's translocation was recorded and analyzed, which suggested that the detected current did not change linearly as commonly expected with increasing biomolecule concentration. On the other hand, detailed translocation information (such as translocation gesture) was also extracted from the discrete current blockages in basic current curves. These results indicated that the nanofluidic device based on the chips integrated by micropores and nanopores possessed comparative potentials in biomolecule sensing. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Korea, Republic of | 1 | 7% |
Unknown | 13 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 43% |
Student > Doctoral Student | 2 | 14% |
Researcher | 1 | 7% |
Unknown | 5 | 36% |
Readers by discipline | Count | As % |
---|---|---|
Engineering | 3 | 21% |
Physics and Astronomy | 2 | 14% |
Agricultural and Biological Sciences | 1 | 7% |
Chemistry | 1 | 7% |
Chemical Engineering | 1 | 7% |
Other | 0 | 0% |
Unknown | 6 | 43% |