Chapter title |
Oligonucleotide Therapeutics in Cancer
|
---|---|
Chapter number | 9 |
Book title |
RNA and Cancer
|
Published in |
Cancer treatment and research, February 2016
|
DOI | 10.1007/978-3-642-31659-3_9 |
Pubmed ID | |
Book ISBNs |
978-3-64-231658-6, 978-3-64-231659-3
|
Authors |
Jing Wan, John A. Bauman, Maria Anna Graziewicz, Peter Sazani, Ryszard Kole, Wan J, Bauman JA, Graziewicz MA, Sazani P, Kole R, Wan, Jing, Bauman, John A., Graziewicz, Maria Anna, Sazani, Peter, Kole, Ryszard |
Abstract |
Alterations in pre-mRNA splicing can have profound effects on gene expression and lead to cellular transformation. Oligonucleotide therapeutics are drugs that manipulate gene expression and improve the disease state. Antisense oligonucleotides hybridize with a target mRNA to downregulate gene expression via an RNase H-dependent mechanism. Additionally, RNase H-independent splice switching oligonucleotides (SSO) modulate alternative or aberrant splicing, to favor the therapeutically relevant splicing product. This chapter summarizes the progress made in the application of these oligonucleotide drugs in the treatment of cancer. |
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