| Chapter title |
Molecular Insights and Functional Implication of LRRK2 Dimerization
|
|---|---|
| Chapter number | 6 |
| Book title |
Leucine-Rich Repeat Kinase 2 (LRRK2)
|
| Published in |
Advances in neurobiology, March 2017
|
| DOI | 10.1007/978-3-319-49969-7_6 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-949967-3, 978-3-31-949969-7
|
| Authors |
Laura Civiero, Isabella Russo, Luigi Bubacco, Elisa Greggio, Civiero, Laura, Russo, Isabella, Bubacco, Luigi, Greggio, Elisa |
| Editors |
Hardy J. Rideout |
| Abstract |
The Parkinson's disease protein leucine-rich repeat kinase 2 (LRRK2) is a multidomain protein with an enzymatic core comprising serine-threonine kinase and GTPase activities and a number of protein-protein interaction domains. While the complex domain architecture of LRRK2 has hampered its structural investigation, there is convincing evidence that LRRK2 can form dimers in solution and in the cell and that the GTPase/ROC domain plays a central role in this process. This chapter focuses on recent studies addressing the molecular nature, the functional significance, and the pathological implication of LRRK2 dimerization. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 23 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 22% |
| Student > Ph. D. Student | 4 | 17% |
| Student > Doctoral Student | 3 | 13% |
| Student > Bachelor | 3 | 13% |
| Professor > Associate Professor | 2 | 9% |
| Other | 1 | 4% |
| Unknown | 5 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 6 | 26% |
| Biochemistry, Genetics and Molecular Biology | 4 | 17% |
| Agricultural and Biological Sciences | 3 | 13% |
| Medicine and Dentistry | 1 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 8 | 35% |