Table of Contents

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   Book Overview
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   Chapter 2 Regulation of DA Homeostasis and Role of VMAT2 in DA-Induced Neurodegeneration
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   Chapter 3 Manganese Neurotoxicity
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   Chapter 4 Links Between Paraquat and Parkinson’s Disease
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   Chapter 5 6-Hydroxydopamine as Preclinical Model of Parkinson’s Disease
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   Chapter 6 Neuroinflammation and Parkinson’s Disease
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   Chapter 7 Dopaminergic Neurons in Parkinson’s Disease
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   Chapter 8 Rotenone as Preclinical Model Compound in Parkinson Disease
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   Chapter 9 Neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) as a Parkinson’s Disease Model
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    Chapter 10 N-Methyl-(R) Salsolinol and the Enzymes Catalyzing its Synthesis and Metabolism in Parkinson’s Disease
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    Chapter 11 Iron Neurotoxicity in Parkinson’s Disease
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    Chapter 12 Neuromelanin and Parkinson’s Disease
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    Chapter 14 Alpha Synuclein in Parkinson’s Disease
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    Chapter 15 Autophagic Pathways and Parkinson Disease
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    Chapter 16 Mechanisms of Dopamine Oxidation and Parkinson’s Disease
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    Chapter 23 Trafficking of Neurotrophins and Their Receptors and Pathological Significance
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    Chapter 24 Synthesis, Trafficking and Release of BDNF
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    Chapter 25 p75NTR Processing and Signaling: Functional Role
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    Chapter 27 NGF/P75 in Cell Cycle and Tetraploidy
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    Chapter 28 p75NTR: A Molecule with Multiple Functions in Amyloid-Beta Metabolism and Neurotoxicity
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    Chapter 29 Neurotrophic Factors and NeuroAIDS: A Lesson from Brain-Derived Neurotrophic Factor
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    Chapter 30 Neurotrophins and Pain
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    Chapter 32 BDNF V66M Polymorphism and Brain Functions
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    Chapter 34 Neurotrophic Therapy for ALS/MND
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    Chapter 36 Neuroprotection in Demyelinating Diseases: The Therapeutic Potential of the Neurotrophins
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    Chapter 37 Blood Brain-Derived Neurotrophic Factor Levels and Mood Disorders
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    Chapter 39 Seizures Tip the Balance of Neurotrophin Signaling Toward Neuronal Death
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    Chapter 41 NGF and Immune Regulation
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    Chapter 43 Amyloid-Beta, BDNF, and the Mechanism of Neurodegeneration in Alzheimer’s Disease
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    Chapter 45 Neurotrophins and p75NTR in Axonal Regeneration and Myelination
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    Chapter 47 Neurotrophic Factors and Ethanol Neurotoxicity
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    Chapter 49 Neurotrophin Signaling in Cancer
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    Chapter 53 Survey of Selective Neurotoxins
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    Chapter 55 Microglia: Neuroprotective and Neurodestructive Properties
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    Chapter 56 RCSN Cell System for Identifying Dopaminergic Neurotoxicity
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    Chapter 59 6-Hydroxydopamine Lesioning of Dopamine Neurons in Neonatal and Adult Rats Induces Age-Dependent Consequences
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    Chapter 70 Dopamine and L-dopa as Selective Endogenous Neurotoxins
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    Chapter 75 Nature of DSP-4-Induced Neurotoxicity
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    Chapter 76 5,6- and 5,7-Dihydroxytryptamines as Serotoninergic Neurotoxins
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    Chapter 77 2′-NH2-MPTP: A Serotonin and Norepinephrine Neurotoxin
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    Chapter 79 Neurotoxic Effects, Mechanisms, and Outcome of 192-IgG Saporin
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    Chapter 80 Methamphetamine and MDMA Neurotoxicity: Biochemical and Molecular Mechanisms
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    Chapter 81 Cocaine as a Neurotoxin
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    Chapter 84 Glutamate as a Neurotoxin
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    Chapter 87 Domoic Acid as a Neurotoxin
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    Chapter 92 Endogenous Kynurenic Acid and Neurotoxicity
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    Chapter 94 TRPV1 Activators (“Vanilloids”) as Neurotoxins
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    Chapter 95 Fusion Models and “Fusioning” in Parkinsonism: Protection and Restoration by Exercise
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    Chapter 98 Experimental Approach to Alzheimer Disease
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    Chapter 100 Iron-Induced Dopaminergic Cell Death In Vivo as a Model of Parkinson’s Disease
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    Chapter 103 Protective Agents in Parkinson's Disease: Caffeine and Adenosine A2A Receptor Antagonists
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    Chapter 104 MPTP: Advances from an Evergreen Neurotoxin
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    Chapter 105 Physical Exercise as Intervention in Parkinsonism
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    Chapter 108 Stem Cell Therapies for Age Associated Neurodegeneration
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    Chapter 110 Neurodegenerative Aspects of Multiple System Atrophy
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    Chapter 115 Molecular, Cellular, and Behavioural Effects Produced by Perinatal Asphyxia: Protection by Poly (ADP-Ribose) Polymerase 1 (PARP-1) Inhibition
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    Chapter 116 Nanomedicines for Nervous System Diseases
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    Chapter 118 Pathophysiology of Obsessive-Compulsive Disorder: Insights from Normal Function and Neurotoxic Effects of Drugs, Infection, and Brain Injury
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    Chapter 119 Neurotoxic Vulnerability Underlying Schizophrenia Spectrum Disorders
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    Chapter 121 Drug Abuse Neurotoxicity: Alcohol and Nicotine as Developmental Stressors
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    Chapter 123 Neurotoxicity of Methamphetamine
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    Chapter 125 Concept of Excitotoxicity via Glutamate Receptors
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    Chapter 126 Ionotropic Receptors in the Central Nervous System and Neurodegenerative Disease
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    Chapter 127 Quinolinate and Related Excitotoxins: Mechanisms of Neurotoxicity and Disease Relevance
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    Chapter 128 Glutamate Neurotoxicity Related to Energy Failure
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    Chapter 129 Glutamate Neurotoxicity, Transport and Alternate Splicing of Transporters
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    Chapter 132 Neurotoxicity and Stroke
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    Chapter 134 Cancer-Mediated Neurotoxicity
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    Chapter 135 Neurotoxicity and Neuroprotection in Spinal Cord Injury
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    Chapter 137 AIDS
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    Chapter 138 Neurotoxicity and ALS: Insights into Pathogenesis
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    Chapter 140 Neurotoxicity in Huntington Disease
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    Chapter 141 Drug Treatments for Alzheimer’s Disease: Hopes and Challenges
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    Chapter 142 Lead and Excitotoxicity
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    Chapter 143 Excitotoxicity in HIV Associated Neurocognitive Disorders
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    Chapter 144 Role of Ionotropic Glutamate Receptors in Neurodegenerative and Other Disorders
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    Chapter 145 Handbook of Neurotoxicity
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    Chapter 146 MS and Excitotoxicity
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    Chapter 147 Excitotoxicity and Amyotrophic Lateral Sclerosis
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    Chapter 148 Excitotoxicity in the Pathogenesis of Autism
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    Chapter 149 Glutamate in the Pathogenesis of Gliomas
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    Chapter 152 Epilepsy
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    Chapter 154 Glutamatergic Receptors in Parkinson’s Disease
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    Chapter 159 Neurotoxicity: A Complex Multistage Process Involving Different Mechanisms
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    Chapter 162 Pathogenesis of Alzheimer’s Disease
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    Chapter 163 Tardive Dyskinesia: Outcome of Antipsychotic Treatment and Brain Damage?
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    Chapter 165 Neuroprotection by Kynurenine Metabolites
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    Chapter 166 Necroptosis, a Potential Therapeutic Target for Neurological Disorders
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    Chapter 167 Molecular Mechanism and Effects of Clostridial Neurotoxins
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    Chapter 168 Neuroprotectants Targeting NMDA Receptor Signaling
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    Chapter 169 Botulinum Neurotoxins as Therapeutics
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    Chapter 170 MPTP Neurotoxicity: Actions, Mechanisms, and Animal Modeling of Parkinson’s Disease
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    Chapter 171 Potential Therapeutic Effects of Statins in Alzheimer’s Disease
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    Chapter 172 Glutamate and Neurodegeneration in the Retina
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    Chapter 173 Neuroprotective Strategies in Amyotrophic Lateral Sclerosis: Modulation of Neurotransmittory and Neurotrophic Input to Motor Neurons
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    Chapter 176 Role of Neurotoxicity in Depression
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    Chapter 177 Advances in Stem Cell Research for Parkinson Disease
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    Chapter 179 Neurotoxicity in Psychostimulant and Opiate Addiction