| Chapter title |
Models of LRRK2-Associated Parkinson’s Disease
|
|---|---|
| Chapter number | 9 |
| Book title |
Leucine-Rich Repeat Kinase 2 (LRRK2)
|
| Published in |
Advances in neurobiology, March 2017
|
| DOI | 10.1007/978-3-319-49969-7_9 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-949967-3, 978-3-31-949969-7
|
| Authors |
Xiong, Yulan, Dawson, Ted M., Dawson, Valina L., Yulan Xiong, Ted M. Dawson, Valina L. Dawson |
| Editors |
Hardy J. Rideout |
| Abstract |
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common genetic causes of Parkinson's disease (PD) and also one of the strongest genetic risk factors in sporadic PD. The LRRK2 protein contains a GTPase and a kinase domain and several protein-protein interaction domains. Both in vitro and in vivo assays in different model systems have provided tremendous insights into the molecular mechanisms underlying LRRK2-induced dopaminergic neurodegeneration. Among all the model systems, animal models are crucial tools to study the pathogenesis of human disease. How do the animal models recapitulate LRRK2-induced dopaminergic neuronal loss in human PD? To answer this question, this review focuses on the discussion of the animal models of LRRK2-associated PD including genetic- and viral-based models. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 84 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 14 | 17% |
| Student > Ph. D. Student | 12 | 14% |
| Researcher | 6 | 7% |
| Student > Bachelor | 5 | 6% |
| Student > Doctoral Student | 4 | 5% |
| Other | 9 | 11% |
| Unknown | 34 | 40% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 18 | 21% |
| Biochemistry, Genetics and Molecular Biology | 11 | 13% |
| Medicine and Dentistry | 6 | 7% |
| Agricultural and Biological Sciences | 3 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
| Other | 4 | 5% |
| Unknown | 39 | 46% |