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Leucine-Rich Repeat Kinase 2 (LRRK2)

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Cover of 'Leucine-Rich Repeat Kinase 2 (LRRK2)'

Table of Contents

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    Book Overview
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    Chapter 1 Leucine-Rich Repeat Kinase (LRRK2) Genetics and Parkinson’s Disease
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    Chapter 2 Clinical Features of LRRK2 Carriers with Parkinson’s Disease
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    Chapter 3 LRRK2 Phosphorylation
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    Chapter 4 Understanding the GTPase Activity of LRRK2: Regulation, Function, and Neurotoxicity
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    Chapter 5 LRRK2 and Autophagy
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    Chapter 6 Molecular Insights and Functional Implication of LRRK2 Dimerization
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    Chapter 7 LRRK2 and the Immune System
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    Chapter 8 Regulation of LRRK2 by Phosphatases
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    Chapter 9 Models of LRRK2-Associated Parkinson’s Disease
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    Chapter 10 LRRK2 and the “LRRKtosome” at the Crossroads of Programmed Cell Death: Clues from RIP Kinase Relatives
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    Chapter 11 Interaction of LRRK2 and α-Synuclein in Parkinson’s Disease
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    Chapter 12 Mechanisms of Mutant LRRK2 Neurodegeneration
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    Chapter 13 Small-Molecule Inhibitors of LRRK2
Attention for Chapter 7: LRRK2 and the Immune System
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Chapter title
LRRK2 and the Immune System
Chapter number 7
Book title
Leucine-Rich Repeat Kinase 2 (LRRK2)
Published in
Advances in neurobiology, March 2017
DOI 10.1007/978-3-319-49969-7_7
Pubmed ID
28353282
Book ISBNs
978-3-31-949967-3, 978-3-31-949969-7
Authors

Dzamko, Nicolas L., Nicolas L. Dzamko

Editors

Hardy J. Rideout

Abstract

Polymorphisms in leucine-rich repeat kinase 2 (LRRK2) have been linked to familial Parkinson's disease, increased risk of sporadic Parkinson's disease, increased risk of Crohn's inflammatory bowel disease, and increased susceptibility to leprosy. As well as LRRK2 mutations, these diseases share in common immune dysfunction and inflammation. LRRK2 is highly expressed in particular immune cells and has been biochemically linked to the intertwined pathways regulating inflammation, mitochondrial function, and autophagy/lysosomal function. This review outlines what is currently understood about LRRK2 function in the immune system and the potential implications of LRRK2 dysfunction for diseases genetically linked to this enigmatic enzyme.

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X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 69 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 14%
Student > Bachelor 10 14%
Researcher 10 14%
Student > Master 10 14%
Student > Doctoral Student 6 9%
Other 5 7%
Unknown 18 26%
Readers by discipline Count As %
Neuroscience 14 20%
Biochemistry, Genetics and Molecular Biology 11 16%
Medicine and Dentistry 10 14%
Agricultural and Biological Sciences 4 6%
Immunology and Microbiology 4 6%
Other 7 10%
Unknown 19 28%

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