| Chapter title |
Sleep Deprivation and Gene Expression.
|
|---|---|
| Chapter number | 360 |
| Book title |
Sleep, Neuronal Plasticity and Brain Function
|
| Published in |
Current topics in behavioral neurosciences, February 2015
|
| DOI | 10.1007/7854_2014_360 |
| Pubmed ID | |
| Book ISBNs |
978-3-66-246877-7, 978-3-66-246878-4
|
| Authors |
Annie da Costa Souza, Sidarta Ribeiro, Costa Souza, Annie, Ribeiro, Sidarta |
| Editors |
Peter Meerlo, Ruth M. Benca, Ted Abel |
| Abstract |
Sleep occurs in a wide range of animal species as a vital process for the maintenance of homeostasis, metabolic restoration, physiological regulation, and adaptive cognitive functions in the central nervous system. Long-term perturbations induced by the lack of sleepSleep are mostly mediated by changes at the level of transcription and translation. This chapter reviews studies in humans, rodents, and flies to address the various ways by which sleep deprivation affects gene expressionGene expression in the nervous system, with a focus on genes related to neuronal plasticity, brain function, and cognitionCognition . However, the effects of sleep deprivation on gene expression and the functional consequences of sleep loss are clearly not restricted to the cognitive domain but may include increased inflammationInflammation , expression of stress-related genes, general impairment of protein translation, metabolic imbalance, and thermalThermoregulation deregulation. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 68 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 11 | 16% |
| Student > Ph. D. Student | 10 | 15% |
| Student > Master | 8 | 12% |
| Researcher | 4 | 6% |
| Professor | 3 | 4% |
| Other | 9 | 13% |
| Unknown | 23 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 11 | 16% |
| Medicine and Dentistry | 8 | 12% |
| Biochemistry, Genetics and Molecular Biology | 5 | 7% |
| Agricultural and Biological Sciences | 5 | 7% |
| Nursing and Health Professions | 3 | 4% |
| Other | 11 | 16% |
| Unknown | 25 | 37% |