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Metastasis Research Protocols

Overview of attention for book
Cover of 'Metastasis Research Protocols'

Table of Contents

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    Book Overview
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    Chapter 1 In Vitro Invasion Assay Using Matrigel™: A Reconstituted Basement Membrane Preparation
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    Chapter 2 Single Cell and Spheroid Collagen Type I Invasion Assay
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    Chapter 3 Rocking Adhesion Assay System to Study Adhesion and Transendothelial Migration of Cancer Cells
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    Chapter 4 Small-Cell Lung Cancer (SCLC) Cell Adhesion on E- and P-Selectin Under Physiological Flow Conditions.
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    Chapter 5 Adhesion of Tumor Cells to Matrices and Endothelium
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    Chapter 6 Cell Aggregation Assays
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    Chapter 7 Chick Heart Invasion Assay
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    Chapter 8 Computer Simulation of the Metastatic Progression
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    Chapter 9 Theoretical Considerations in Using Animal Models of Metastasis and Brief Methodology for In Vivo Colorectal Cancer Models in SCID and Nude Mice
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    Chapter 10 Syngeneic Murine Metastasis Models: B16 Melanoma
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    Chapter 11 Imageable Clinically Relevant Mouse Models of Metastasis
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    Chapter 12 Imaging metastatic cell trafficking at the cellular level in vivo with fluorescent proteins.
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    Chapter 13 Ultrasound Techniques for the Detection of Tumors and Metastases in Small Animals
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    Chapter 14 The PFP/RAG2 Double-Knockout Mouse in Metastasis Research: Small-Cell Lung Cancer and Prostate Cancer.
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    Chapter 15 Ultrasound-Guided Intracardial Injection and In Vivo Magnetic Resonance Imaging of Single Cells in Mice as a Paradigm for Hematogenous Metastases.
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    Chapter 16 Magnetic Resonance Imaging of Metastases in Xenograft Mouse Models of Cancer
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    Chapter 17 Spontaneous and Experimental Metastasis Models: Nude Mice
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    Chapter 18 Identifying the Origin and Phenotype of Cells in Tumor Xenografts
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    Chapter 19 Erratum
Attention for Chapter 4: Small-Cell Lung Cancer (SCLC) Cell Adhesion on E- and P-Selectin Under Physiological Flow Conditions.
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Chapter title
Small-Cell Lung Cancer (SCLC) Cell Adhesion on E- and P-Selectin Under Physiological Flow Conditions.
Chapter number 4
Book title
Metastasis Research Protocols
Published in
Methods in molecular biology, January 2014
DOI 10.1007/978-1-4614-8244-4_4
Pubmed ID
24092431
Book ISBNs
978-1-4614-8243-7, 978-1-4614-8244-4
Authors

Ulrich Richter, Richter, Ulrich

Abstract

Hematogenous metastasis is still a poorly understood phenomenon. The rate-limiting step within the metastatic cascade is not yet clear although it may be estimated that the extravasation of circulating tumor cells is a step of crucial importance, as most tumor cells that are shed into circulation undergo apoptosis. The process of extravasation includes a cascade of consecutive steps, starting with adhesion of tumor cells circulating in the bloodstream to endothelial cells, mimicking leukocyte adhesion and transmigration. Endothelial cell selectin-leukocyte glycan interaction occurs when leukocytes adhere to endothelial cells under conditions of shear stress. As there are parallels between cancer cell endothelial interactions with leukocyte endothelial cell systems an experimental setup has been developed in which adhesion of small cell lung carcinoma adhesive properties can be analyzed under physiological shear stress conditions during their attachment to E- and P-selection.

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X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 6 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 2 33%
Professor > Associate Professor 1 17%
Researcher 1 17%
Student > Doctoral Student 1 17%
Unknown 1 17%
Readers by discipline Count As %
Medicine and Dentistry 2 33%
Agricultural and Biological Sciences 2 33%
Pharmacology, Toxicology and Pharmaceutical Science 1 17%
Unknown 1 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 October 2013.
All research outputs
#20,205,224
of 22,725,280 outputs
Outputs from Methods in molecular biology
#9,856
of 13,085 outputs
Outputs of similar age
#264,694
of 305,147 outputs
Outputs of similar age from Methods in molecular biology
#402
of 594 outputs
Altmetric has tracked 22,725,280 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,085 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 305,147 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 594 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.

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