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Behavioral neuroscience of drug addiction

Overview of attention for book
Attention for Chapter 23: Neuroplastic Alterations in the Limbic System Following Cocaine or Alcohol Exposure
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Chapter title
Neuroplastic Alterations in the Limbic System Following Cocaine or Alcohol Exposure
Chapter number 23
Book title
Behavioral Neuroscience of Drug Addiction
Published in
Current topics in behavioral neurosciences, January 2010
DOI 10.1007/7854_2009_23
Pubmed ID
Book ISBNs
978-3-64-203000-0, 978-3-64-203001-7
Authors

Antonello Bonci, Garret D. Stuber, F. Woodward Hopf, Kay M. Tye, Billy T. Chen

Abstract

Neuroplastic changes in the CNS are thought to be a fundamental component of learning and memory. While pioneering studies in the hippocampus and cerebellum have detailed many of the basic mechanisms that can lead to alterations in synaptic transmission based on previous activity, only more recently has synaptic plasticity been monitored after behavioral manipulation or drug exposure. In this chapter, we review evidence that drugs of abuse are powerful modulators of synaptic plasticity. Both the dopaminergic neurons of the ventral tegmental area as well medium spiny neurons in nucleus accumbens show enhanced excitatory synaptic strength following passive or active exposure to drugs such as cocaine and alcohol. In the VTA, both the enhancement of excitatory synaptic strength and the acquisition of drug-related behaviors depend on signaling through the N-methyl-D: -aspartate receptors (NMDARs) which are mechanistically thought to lead to increased synaptic insertion of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs). Synaptic insertion of AMPARs by drugs of abuse can be long lasting, depending on the route of administration, number of drug exposures, or whether the drugs are received passively or self-administered.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 7%
Netherlands 1 1%
Germany 1 1%
Spain 1 1%
United Kingdom 1 1%
Unknown 62 87%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 18%
Researcher 9 13%
Student > Bachelor 8 11%
Student > Doctoral Student 6 8%
Student > Postgraduate 6 8%
Other 14 20%
Unknown 15 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 19 27%
Neuroscience 13 18%
Medicine and Dentistry 9 13%
Psychology 5 7%
Biochemistry, Genetics and Molecular Biology 1 1%
Other 4 6%
Unknown 20 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 October 2012.
All research outputs
#15,253,344
of 22,681,577 outputs
Outputs from Current topics in behavioral neurosciences
#315
of 486 outputs
Outputs of similar age
#134,063
of 163,553 outputs
Outputs of similar age from Current topics in behavioral neurosciences
#4
of 7 outputs
Altmetric has tracked 22,681,577 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 486 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 163,553 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.