| Chapter title |
The roles of retinoic Acid and retinoic Acid receptors in inducing epigenetic changes.
|
|---|---|
| Chapter number | 7 |
| Book title |
The Biochemistry of Retinoic Acid Receptors I: Structure, Activation, and Function at the Molecular Level
|
| Published in |
Sub cellular biochemistry, June 2014
|
| DOI | 10.1007/978-94-017-9050-5_7 |
| Pubmed ID | |
| Book ISBNs |
978-9-40-179049-9, 978-9-40-179050-5
|
| Authors |
Alison Urvalek, Kristian Bruun Laursen, Lorraine J Gudas, Urvalek A, Laursen KB, Gudas LJ, Lorraine J. Gudas, Urvalek, Alison, Laursen, Kristian Bruun, Gudas, Lorraine J. |
| Editors |
Mary Ann Asson-Batres, Cécile Rochette-Egly |
| Abstract |
Epigenetics is "the branch of biology which studies the causal interactions between genes and their products which bring the phenotype into being" as defined by Conrad Waddington in 1942 in a discussion of the mechanisms of cell differentiation. More than seven decades later we know that these mechanisms include histone tail post-translational modifications, DNA methylation, ATP-dependent chromatin remodeling, and non-coding RNA pathways. Epigenetic modifications are powerful drugs targets, and combined targeting of multiple pathways is expected to significantly advance cancer therapy. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 33% |
| United Kingdom | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| Unknown | 55 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 25% |
| Researcher | 8 | 14% |
| Student > Master | 7 | 13% |
| Student > Postgraduate | 4 | 7% |
| Student > Bachelor | 3 | 5% |
| Other | 9 | 16% |
| Unknown | 11 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 19 | 34% |
| Medicine and Dentistry | 7 | 13% |
| Agricultural and Biological Sciences | 7 | 13% |
| Chemistry | 3 | 5% |
| Neuroscience | 2 | 4% |
| Other | 6 | 11% |
| Unknown | 12 | 21% |