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Matrix Metalloproteases

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Cover of 'Matrix Metalloproteases'

Table of Contents

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    Book Overview
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    Chapter 1 Expression and Purification of Matrix Metalloproteinases in Escherichia coli
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    Chapter 2 Expression and Purification of a Matrix Metalloprotease Transmembrane Domain in Escherichia coli
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    Chapter 3 Heterologous Expression of the Astacin Protease Meprin β in Pichia pastoris
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    Chapter 4 Structural Studies of Matrix Metalloproteinase by X-Ray Diffraction
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    Chapter 5 Mapping Lipid Bilayer Recognition Sites of Metalloproteinases and Other Prospective Peripheral Membrane Proteins
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    Chapter 6 Using Small Angle X-Ray Scattering (SAXS) to Characterize the Solution Conformation and Flexibility of Matrix Metalloproteinases (MMPs)
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    Chapter 7 Molecular Dynamics Studies of Matrix Metalloproteases
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    Chapter 8 Determining the Substrate Specificity of Matrix Metalloproteases using Fluorogenic Peptide Substrates
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    Chapter 9 Time-Resolved Analysis of Matrix Metalloproteinase Substrates in Complex Samples
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    Chapter 10 Identification of Protease Cleavage Sites by Charge-Based Enrichment of Protein N-Termini
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    Chapter 11 Mapping the Substrate Recognition Landscapes of Metalloproteases Using Comprehensive Mutagenesis
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    Chapter 12 Detection of Matrix Metalloproteinases by Zymography
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    Chapter 13 Imaging Matrix Metalloproteases in Spontaneous Colon Tumors: Validation by Correlation with Histopathology
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    Chapter 14 Virtual High-Throughput Screening for Matrix Metalloproteinase Inhibitors
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    Chapter 15 Computational Approaches to Matrix Metalloprotease Drug Design
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    Chapter 16 A Simple Adaptable Blood-Brain Barrier Cell Model for Screening Matrix Metalloproteinase Inhibitor Functionality
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    Chapter 17 Matrix Metalloproteases as Biomarkers of Disease
Attention for Chapter 17: Matrix Metalloproteases as Biomarkers of Disease
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Chapter title
Matrix Metalloproteases as Biomarkers of Disease
Chapter number 17
Book title
Matrix Metalloproteases
Published in
Methods in molecular biology, March 2017
DOI 10.1007/978-1-4939-6863-3_17
Pubmed ID
Book ISBNs
978-1-4939-6861-9, 978-1-4939-6863-3
Authors

Fernando Luiz Affonso Fonseca, Beatriz da Costa Aguiar Alves, Ligia Ajaime Azzalis, Thaís Moura Gáscon Belardo

Editors

Charles A. Galea

Abstract

Matrix metalloprotease play a vital role in many cellular processes. Dysfunction in activity of these enzymes has been implicated in the pathogenesis of a number of diseases. Factors that affect the balanced interaction between MMPs and their inhibitors, such as genetic mutations of extracellular matrix components or dysregulation of MMP expression, can lead to various diseases. Due to their essential role in ECM remodeling, MMPs have become targets of interest as biomarkers for the diagnosis and prognosis of diseases associated with alterations of the ECM.

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Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 2 25%
Student > Ph. D. Student 1 13%
Student > Master 1 13%
Unknown 4 50%
Readers by discipline Count As %
Medicine and Dentistry 2 25%
Unspecified 1 13%
Unknown 5 63%