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Matrix Metalloproteases

Overview of attention for book
Cover of 'Matrix Metalloproteases'

Table of Contents

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    Book Overview
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    Chapter 1 Expression and Purification of Matrix Metalloproteinases in Escherichia coli
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    Chapter 2 Expression and Purification of a Matrix Metalloprotease Transmembrane Domain in Escherichia coli
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    Chapter 3 Heterologous Expression of the Astacin Protease Meprin β in Pichia pastoris
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    Chapter 4 Structural Studies of Matrix Metalloproteinase by X-Ray Diffraction
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    Chapter 5 Mapping Lipid Bilayer Recognition Sites of Metalloproteinases and Other Prospective Peripheral Membrane Proteins
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    Chapter 6 Using Small Angle X-Ray Scattering (SAXS) to Characterize the Solution Conformation and Flexibility of Matrix Metalloproteinases (MMPs)
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    Chapter 7 Molecular Dynamics Studies of Matrix Metalloproteases
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    Chapter 8 Determining the Substrate Specificity of Matrix Metalloproteases using Fluorogenic Peptide Substrates
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    Chapter 9 Time-Resolved Analysis of Matrix Metalloproteinase Substrates in Complex Samples
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    Chapter 10 Identification of Protease Cleavage Sites by Charge-Based Enrichment of Protein N-Termini
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    Chapter 11 Mapping the Substrate Recognition Landscapes of Metalloproteases Using Comprehensive Mutagenesis
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    Chapter 12 Detection of Matrix Metalloproteinases by Zymography
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    Chapter 13 Imaging Matrix Metalloproteases in Spontaneous Colon Tumors: Validation by Correlation with Histopathology
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    Chapter 14 Virtual High-Throughput Screening for Matrix Metalloproteinase Inhibitors
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    Chapter 15 Computational Approaches to Matrix Metalloprotease Drug Design
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    Chapter 16 A Simple Adaptable Blood-Brain Barrier Cell Model for Screening Matrix Metalloproteinase Inhibitor Functionality
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    Chapter 17 Matrix Metalloproteases as Biomarkers of Disease
Attention for Chapter 13: Imaging Matrix Metalloproteases in Spontaneous Colon Tumors: Validation by Correlation with Histopathology
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Chapter title
Imaging Matrix Metalloproteases in Spontaneous Colon Tumors: Validation by Correlation with Histopathology
Chapter number 13
Book title
Matrix Metalloproteases
Published in
Methods in molecular biology, March 2017
DOI 10.1007/978-1-4939-6863-3_13
Pubmed ID
28299741
Book ISBNs
978-1-4939-6861-9, 978-1-4939-6863-3
Authors

Hensley, Harvey, Cooper, Harry S., Chang, Wen-Chi L., Clapper, Margie L., Harvey Hensley, Harry S. Cooper, Wen-Chi L. Chang, Margie L. Clapper

Editors

Charles A. Galea

Abstract

The use of fluorescent probes in conjunction with white-light colonoscopy is a promising strategy for improving the detection of precancerous colorectal lesions, in particular flat (sessile) lesions that do not protrude into the lumen of the colon. We describe a method for determining the sensitivity and specificity of an enzymatically activated near-infrared probe (MMPSense680) for the detection of colon lesions in a mouse model (APC(+/Min-FCCC)) of spontaneous colorectal cancer. Fluorescence intensity correlates directly with the activity of matrix metalloproteinases (MMPs). Overexpression of MMPs is an early event in the development of colorectal lesions. Although the probe employed serves as a reporter of the activity of MMPs, our method can be applied to any fluorescent probe that targets an early molecular event in the development of colorectal tumors.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 33%
Professor 1 11%
Researcher 1 11%
Student > Bachelor 1 11%
Unknown 3 33%
Readers by discipline Count As %
Medicine and Dentistry 4 44%
Biochemistry, Genetics and Molecular Biology 1 11%
Social Sciences 1 11%
Computer Science 1 11%
Unknown 2 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 March 2017.
All research outputs
#18,538,272
of 22,959,818 outputs
Outputs from Methods in molecular biology
#7,936
of 13,136 outputs
Outputs of similar age
#235,310
of 308,425 outputs
Outputs of similar age from Methods in molecular biology
#187
of 313 outputs
Altmetric has tracked 22,959,818 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,136 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 308,425 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 313 others from the same source and published within six weeks on either side of this one. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.

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