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Socioeconomic Status and the Cerebellar Grey Matter Volume. Data from a Well-Characterised Population Sample

Overview of attention for article published in The Cerebellum, June 2013
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Title
Socioeconomic Status and the Cerebellar Grey Matter Volume. Data from a Well-Characterised Population Sample
Published in
The Cerebellum, June 2013
DOI 10.1007/s12311-013-0497-4
Pubmed ID
Authors

Jonathan Cavanagh, Rajeev Krishnadas, G. David Batty, Harry Burns, Kevin A. Deans, Ian Ford, Alex McConnachie, Agnes McGinty, Jennifer S. McLean, Keith Millar, Naveed Sattar, Paul G. Shiels, Carol Tannahill, Yoga N. Velupillai, Chris J. Packard, John McLean

Abstract

The cerebellum is highly sensitive to adverse environmental factors throughout the life span. Socioeconomic deprivation has been associated with greater inflammatory and cardiometabolic risk, and poor neurocognitive function. Given the increasing awareness of the association between early-life adversities on cerebellar structure, we aimed to explore the relationship between early life (ESES) and current socioeconomic status (CSES) and cerebellar volume. T1-weighted MRI was used to create models of cerebellar grey matter volumes in 42 adult neurologically healthy males selected from the Psychological, Social and Biological Determinants of Ill Health study. The relationship between potential risk factors, including ESES, CSES and cerebellar grey matter volumes were examined using multiple regression techniques. We also examined if greater multisystem physiological risk index-derived from inflammatory and cardiometabolic risk markers-mediated the relationship between socioeconomic status (SES) and cerebellar grey matter volume. Both ESES and CSES explained the greatest variance in cerebellar grey matter volume, with age and alcohol use as a covariate in the model. Low CSES explained additional significant variance to low ESES on grey matter decrease. The multisystem physiological risk index mediated the relationship between both early life and current SES and grey matter volume in cerebellum. In a randomly selected sample of neurologically healthy males, poorer socioeconomic status was associated with a smaller cerebellar volume. Early and current socioeconomic status and the multisystem physiological risk index also apparently influence cerebellar volume. These findings provide data on the relationship between socioeconomic deprivation and a brain region highly sensitive to environmental factors.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 80 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 14%
Student > Master 9 11%
Researcher 8 10%
Professor > Associate Professor 7 9%
Student > Bachelor 4 5%
Other 14 18%
Unknown 27 34%
Readers by discipline Count As %
Psychology 20 25%
Medicine and Dentistry 8 10%
Neuroscience 5 6%
Social Sciences 5 6%
Agricultural and Biological Sciences 3 4%
Other 5 6%
Unknown 34 43%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 December 2013.
All research outputs
#19,495,804
of 23,975,976 outputs
Outputs from The Cerebellum
#659
of 957 outputs
Outputs of similar age
#151,243
of 200,049 outputs
Outputs of similar age from The Cerebellum
#7
of 14 outputs
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