| Chapter title |
Pharmacological Tool Compounds for the Free Fatty Acid Receptor 4 (FFA4/GPR120)
|
|---|---|
| Chapter number | 60 |
| Book title |
Free Fatty Acid Receptors
|
| Published in |
Handbook of experimental pharmacology, November 2016
|
| DOI | 10.1007/164_2016_60 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-950692-0, 978-3-31-950693-7
|
| Authors |
Steffen V. F. Hansen, Trond Ulven |
| Editors |
Graeme Milligan, Ikuo Kimura |
| Abstract |
The free fatty acid receptor 4 (FFA4), also known as GPR120, is a G protein-coupled receptor that is activated by long-chain fatty acids and that has been associated with regulation of appetite, release of insulin controlling hormones, insulin sensitization, anti-inflammatory and potentially anti-obesity activity, and is progressively appearing as an attractive potential target for the treatment of metabolic dysfunctions such as obesity, type 2 diabetes and inflammatory disorders. Ongoing investigations of the pharmacological functions of FFA4 and validation of its potential as a therapeutic target depend critically on the appropriateness and quality of the available pharmacological probes or tool compounds. After a brief summary of the pharmacological functions of FFA4 and some general considerations on desirable properties for these pharmacological tool compounds, the individual compounds that have been or are currently being used as tools for probing the function of FFA4 in various in vitro and in vivo settings will be discussed and evaluated. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 13 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 3 | 23% |
| Student > Bachelor | 3 | 23% |
| Researcher | 2 | 15% |
| Professor | 1 | 8% |
| Other | 1 | 8% |
| Other | 0 | 0% |
| Unknown | 3 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Nursing and Health Professions | 3 | 23% |
| Medicine and Dentistry | 2 | 15% |
| Chemistry | 2 | 15% |
| Agricultural and Biological Sciences | 1 | 8% |
| Neuroscience | 1 | 8% |
| Other | 1 | 8% |
| Unknown | 3 | 23% |