Reverse Engineering of Regulatory Networks

Kathiresan, Nachammai, Ramachandran, Srinithi, Kulanthaivel, Langeswaran

Next-generation sequencing (NGS) has transformed genomics by allowing researchers to sequence DNA and RNA at highest speed, accuracy, and cost-effectiveness. Researchers investigate DNA interactions with the help next-generation sequencing with a great deal of information. Over the last decade, NGS technologies have advanced significantly, with the development of several platforms, including Illumina, PacBio, and Oxford Nanopore, each offering distinct advantages and uses. The use of next-generation sequencing (NGS) has aided in the discovery of genetic variations, gene expression patterns, and epigenetic modifications connected with a variety of diseases, including cancer, neurological disorders, and infectious diseases. By identifying these regions, we can control the expression of genes, cellular signaling pathways, and other key biological processes. NGS is an effective method for researching DNA interactions that has completely transformed the area of genomics. NGS has also played an important part in personalized medicine, enabling the discovery of disease-causing mutations and the creation of targeted medicines. Finally, NGS has transformed the field of genomics, resulting in new discoveries and applications in medicine, environmental sciences, and other fields.