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Nipah Virus

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Attention for Chapter: Cell-Cell Fusion Assays to Study Henipavirus Entry and Evaluate Therapeutics.
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Chapter title
Cell-Cell Fusion Assays to Study Henipavirus Entry and Evaluate Therapeutics.
Book title
Nipah Virus
Published in
Methods in molecular biology, January 2023
DOI 10.1007/978-1-0716-3283-3_4
Pubmed ID
Book ISBNs
978-1-07-163282-6, 978-1-07-163283-3
Authors

Monreal, I Abrrey, Aguilar, Hector C, Monreal, I. Abrrey, Aguilar, Hector C.

Abstract

Henipaviruses include the deadly zoonotic Nipah (NiV) and Hendra (HeV) paramyxoviruses, which have caused recurring outbreaks in human populations. A hallmark of henipavirus infection is the induction of cell-cell fusion (syncytia), caused by the expression of the attachment (G) and fusion (F) glycoproteins on the surface of infected cells. The interactions of G and F with each other and with receptors on cellular plasma membranes drive both viral entry and syncytia formation and are thus of great interest. While F shares structural and functional homologies with class I fusion proteins of other viruses such as influenza and human immunodeficiency viruses, the intricate interactions between the G and F glycoproteins allow for unique approaches to studying the class I membrane fusion process. This allows us to study cell-cell fusion and viral entry kinetics for BSL-4 pathogens such as NiV and HeV under BSL-2 conditions using recombinant DNA techniques. Here, we present approaches to studying henipavirus-induced membrane fusion for currently identified and emerging henipaviruses, including more traditional syncytia counting-based cell-cell fusion assay and a new heterologous fluorescent dye exchange cell-cell fusion assay.

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Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 August 2023.
All research outputs
#17,285,933
of 25,380,192 outputs
Outputs from Methods in molecular biology
#5,993
of 14,200 outputs
Outputs of similar age
#270,444
of 478,823 outputs
Outputs of similar age from Methods in molecular biology
#287
of 722 outputs
Altmetric has tracked 25,380,192 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 14,200 research outputs from this source. They receive a mean Attention Score of 3.5. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 478,823 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 722 others from the same source and published within six weeks on either side of this one. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.