Tandem Repeats in Genes, Proteins, and Disease
Humana Press
Chapter title |
Immuno-based Detection Assays to Quantify Distinct Mutant Huntingtin Conformations in Biological Samples.
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Chapter number | 12 |
Book title |
Tandem Repeats in Genes, Proteins, and Disease
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Published in |
Methods in molecular biology, January 2013
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DOI | 10.1007/978-1-62703-438-8_12 |
Pubmed ID | |
Book ISBNs |
978-1-62703-437-1, 978-1-62703-438-8
|
Authors |
Lotz, Gregor P, Weiss, Andreas, Gregor P. Lotz, Andreas Weiss |
Abstract |
A pathological hallmark of many protein-misfolding diseases is the formation of insoluble aggregates. Quantitative methods are needed to better resolve and define the formation, aggregation, and temporal dynamics of soluble misfolded proteins in native settings. In this book chapter we describe simple and sensitive detection methods to characterize high ordered aggregates (AGERA) and subsets of distinct soluble aggregates (SEC-FRET) of mutant huntingtin protein in biological samples. |
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