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Tandem Repeats in Genes, Proteins, and Disease

Overview of attention for book
Tandem Repeats in Genes, Proteins, and Disease
Humana Press

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Longitudinal Imaging and Analysis of Neurons Expressing Polyglutamine-Expanded Proteins
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    Chapter 2 Atomic Force Microscopy Assays for Evaluating Polyglutamine Aggregation in Solution and on Surfaces
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    Chapter 3 Morphometric Analysis of Huntington's Disease Neurodegeneration in Drosophila.
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    Chapter 4 Size analysis of polyglutamine protein aggregates using fluorescence detection in an analytical ultracentrifuge.
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    Chapter 5 A Method for the Incremental Expansion of Polyglutamine Repeats in Recombinant Proteins
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    Chapter 6 Tandem Repeats in Genes, Proteins, and Disease
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    Chapter 7 Characterizing social behavior in genetically targeted mouse models of brain disorders.
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    Chapter 8 PCR Amplification and Sequence Analysis of GC-Rich Sequences: Aristaless-Related Homeobox Example
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    Chapter 9 Challenges of “Sticky” Co-immunoprecipitation: Polyalanine Tract Protein–Protein Interactions
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    Chapter 10 Molecular Pathology of Polyalanine Expansion Disorders: New Perspectives from Mouse Models
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    Chapter 11 Yeast as a platform to explore polyglutamine toxicity and aggregation.
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    Chapter 12 Immuno-based Detection Assays to Quantify Distinct Mutant Huntingtin Conformations in Biological Samples.
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    Chapter 13 Modeling and Analysis of Repeat RNA Toxicity in Drosophila
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    Chapter 14 Analyzing Modifiers of Protein Aggregation in C. elegans by Native Agarose Gel Electrophoresis.
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    Chapter 15 Kinetic Analysis of Aggregation Data
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    Chapter 16 Tandem Repeats in Genes, Proteins, and Disease
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    Chapter 17 Detecting Soluble PolyQ Oligomers and Investigating Their Impact on Living Cells Using Split-GFP
  19. Altmetric Badge
    Chapter 18 Cell Biological Approaches to Investigate Polyglutamine-Expanded AR Metabolism
Attention for Chapter 12: Immuno-based Detection Assays to Quantify Distinct Mutant Huntingtin Conformations in Biological Samples.
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Chapter title
Immuno-based Detection Assays to Quantify Distinct Mutant Huntingtin Conformations in Biological Samples.
Chapter number 12
Book title
Tandem Repeats in Genes, Proteins, and Disease
Published in
Methods in molecular biology, January 2013
DOI 10.1007/978-1-62703-438-8_12
Pubmed ID
Book ISBNs
978-1-62703-437-1, 978-1-62703-438-8
Authors

Lotz, Gregor P, Weiss, Andreas, Gregor P. Lotz, Andreas Weiss

Abstract

A pathological hallmark of many protein-misfolding diseases is the formation of insoluble aggregates. Quantitative methods are needed to better resolve and define the formation, aggregation, and temporal dynamics of soluble misfolded proteins in native settings. In this book chapter we describe simple and sensitive detection methods to characterize high ordered aggregates (AGERA) and subsets of distinct soluble aggregates (SEC-FRET) of mutant huntingtin protein in biological samples.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 27%
Student > Doctoral Student 2 18%
Researcher 2 18%
Student > Bachelor 1 9%
Professor > Associate Professor 1 9%
Other 0 0%
Unknown 2 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 55%
Agricultural and Biological Sciences 2 18%
Neuroscience 1 9%
Unknown 2 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 June 2013.
All research outputs
#18,340,012
of 22,711,645 outputs
Outputs from Methods in molecular biology
#7,851
of 13,079 outputs
Outputs of similar age
#218,027
of 280,736 outputs
Outputs of similar age from Methods in molecular biology
#220
of 341 outputs
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So far Altmetric has tracked 13,079 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
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We're also able to compare this research output to 341 others from the same source and published within six weeks on either side of this one. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.