| Chapter title |
L1 Retrotransposition in Neural Progenitor Cells. - PubMed - NCBI
|
|---|---|
| Chapter number | 11 |
| Book title |
Transposons and Retrotransposons
|
| Published in |
Methods in molecular biology, January 2016
|
| DOI | 10.1007/978-1-4939-3372-3_11 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-3370-9, 978-1-4939-3372-3
|
| Authors |
Muotri, Alysson R, Alysson R. Muotri Ph.D., Alysson R. Muotri |
| Editors |
Jose L. Garcia-Pérez |
| Abstract |
Long interspersed nucleotide element 1 (LINE-1 or L1) is a family of non-LTR retrotransposons that can replicate and reintegrate into the host genome. L1s have considerably influenced mammalian genome evolution by retrotransposing during germ cell development or early embryogenesis, leading to massive genome expansion. For many years, L1 retrotransposons were viewed as a selfish DNA parasite that had no contribution in somatic cells. Historically, L1s were thought to only retrotranspose during gametogenesis and in neoplastic processes, but recent studies have shown that L1s are extremely active in the mouse, rat, and human neuronal progenitor cells (NPCs). These de novo L1 insertions can impact neuronal transcriptional expression, creating unique transcriptomes of individual neurons, possibly contributing to the uniqueness of the individual cognition and mental disorders in humans. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Spain | 1 | 1% |
| United States | 1 | 1% |
| Australia | 1 | 1% |
| Unknown | 91 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 23% |
| Researcher | 21 | 22% |
| Student > Bachelor | 12 | 13% |
| Student > Master | 12 | 13% |
| Other | 5 | 5% |
| Other | 13 | 14% |
| Unknown | 10 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 32 | 34% |
| Agricultural and Biological Sciences | 31 | 33% |
| Medicine and Dentistry | 8 | 8% |
| Neuroscience | 6 | 6% |
| Immunology and Microbiology | 1 | 1% |
| Other | 7 | 7% |
| Unknown | 10 | 11% |