Characterization of Protein Therapeutics using Mass Spectrometry

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Cover of 'Characterization of Protein Therapeutics using Mass Spectrometry'

Table of Contents

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Book Overview
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Chapter 1 Introduction to Protein Mass Spectrometry
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Chapter 2 Quantitative Analysis of Therapeutic and Endogenous Peptides using LC/MS/MS Methods
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Chapter 3 The Development and Implementation of LC/MS-Based Bioanalytical Methods for the Quantification of Protein Therapeutics in Drug Discovery
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Chapter 4 Post-Translationally Modified Proteins: Glycosylation and Disulfide Bond Formation
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Chapter 5 Mass Spectrometric Characterization in Protein Therapeutics Discovery
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Chapter 6 Molecular Variants Characterization in Protein Therapeutics Development
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Chapter 7 Mass Spectrometry of Antibody–Drug Conjugates in Plasma and Tissue in Drug Development
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Chapter 8 Hydrogen/Deuterium Exchange Mass Spectrometry for Protein Higher-Order Structure Characterization
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Chapter 9 Fast Photochemical Oxidation of Proteins for Structural Characterization
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Chapter 10 Applications of Ion Mobility Mass Spectrometry for Characterization of Protein Therapeutics

Attention for Chapter 9: Fast Photochemical Oxidation of Proteins for Structural Characterization

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Citations

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Basic Regulatory Science Behind Drug Substance and Drug Product Specifications of Monoclonal Antibodies and Other Protein Therapeutics

Article in Journal of Pharmaceutical Analysis (December 2023)

Recent advancements in mass spectrometry for higher order structure characterization of protein therapeutics

Article in Drug Discovery Today (September 2021)

Characterization of R-Loop–Interacting Proteins in Embryonic Stem Cells Reveals Roles in rRNA Processing and Gene Expression

Article in Molecular & Cellular Proteomics (August 2021)

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