Chapter title |
Social Interactions and Indirect Genetic Effects on Complex Juvenile and Adult Traits
|
---|---|
Chapter number | 24 |
Book title |
Systems Genetics
|
Published in |
Methods in molecular biology, January 2017
|
DOI | 10.1007/978-1-4939-6427-7_24 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6425-3, 978-1-4939-6427-7
|
Authors |
David G. Ashbrook, Reinmar Hager |
Editors |
Klaus Schughart, Robert W. Williams |
Abstract |
Most animal species are social in one form or another, yet many studies in rodent model systems use either individually housed animals or ignore potential confounds caused by group housing. While such social interaction effects on developmental and behavioral traits are well established, the genetic basis of social interactions has not been researched in as much detail. Specifically, the effects of genetic variation in social partners on the phenotype of a focal individual have mostly been studied at the phenotypic level. Such indirect genetic effects (IGEs), where the genotype of one individual influences the phenotype of a second individual, can have important evolutionary and medically relevant consequences. In this chapter, we give a brief outline of social interaction effects, and how systems genetics approaches using recombinant inbred populations can be used to investigate indirect genetic effects specifically, including maternal genetic effects. We discuss experimental designs for the study of IGEs and show how indirect genetic loci can be identified that underlie social interaction effects, their mechanisms, and consequences for trait variation in focal individuals. |
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