Chapter title |
Complex Genetics of Behavior: BXDs in the Automated Home-Cage
|
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Chapter number | 25 |
Book title |
Systems Genetics
|
Published in |
Methods in molecular biology, January 2017
|
DOI | 10.1007/978-1-4939-6427-7_25 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6425-3, 978-1-4939-6427-7
|
Authors |
Maarten Loos Ph.D., Matthijs Verhage, Sabine Spijker, August B. Smit, Maarten Loos |
Editors |
Klaus Schughart, Robert W. Williams |
Abstract |
This chapter describes a use case for the genetic dissection and automated analysis of complex behavioral traits using the genetically diverse panel of BXD mouse recombinant inbred strains. Strains of the BXD resource differ widely in terms of gene and protein expression in the brain, as well as in their behavioral repertoire. A large mouse resource opens the possibility for gene finding studies underlying distinct behavioral phenotypes, however, such a resource poses a challenge in behavioral phenotyping. To address the specifics of large-scale screening we describe how to investigate: (1) how to assess mouse behavior systematically in addressing a large genetic cohort, (2) how to dissect automation-derived longitudinal mouse behavior into quantitative parameters, and (3) how to map these quantitative traits to the genome, deriving loci underlying aspects of behavior. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 10 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 3 | 30% |
Other | 2 | 20% |
Student > Bachelor | 1 | 10% |
Student > Master | 1 | 10% |
Student > Ph. D. Student | 1 | 10% |
Other | 0 | 0% |
Unknown | 2 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 2 | 20% |
Medicine and Dentistry | 2 | 20% |
Mathematics | 1 | 10% |
Arts and Humanities | 1 | 10% |
Agricultural and Biological Sciences | 1 | 10% |
Other | 0 | 0% |
Unknown | 3 | 30% |