Chapter title |
Gene Expression Analysis Through Network Biology: Bioinformatics Approaches.
|
---|---|
Chapter number | 44 |
Book title |
Network Biology
|
Published in |
Advances in biochemical engineering biotechnology, January 2016
|
DOI | 10.1007/10_2016_44 |
Pubmed ID | |
Book ISBNs |
978-3-31-956459-3, 978-3-31-956460-9
|
Authors |
Kanthida Kusonmano |
Abstract |
Following the availability of high-throughput technologies, vast amounts of biological data have been generated. Gene expression is one example of the popular data that has been utilized for studying cellular systems in the tran scriptional level. Several bioinformatics approaches have been developed to analyze such data. A typical expression analysis identifies a ranked list of individual significant differentially expressed genes between two conditions of interest. However, it has been accepted that biomolecules in a living organism are working together and interacting with each other. Study through network analysis could be complementary to typical expression analysis and provides more contexts to understanding the biological systems. Conversely, expression data could provide clues to functional links between biomolecules in biological networks. In this chapter, bioinformatics approaches to analyze expression data in network levels including basic concepts of network biology are described. Different concepts to integrate expression data with interactome data and example studies are explained. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 24 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 21% |
Student > Master | 3 | 13% |
Student > Bachelor | 3 | 13% |
Researcher | 2 | 8% |
Student > Doctoral Student | 1 | 4% |
Other | 3 | 13% |
Unknown | 7 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 4 | 17% |
Agricultural and Biological Sciences | 2 | 8% |
Social Sciences | 2 | 8% |
Engineering | 2 | 8% |
Computer Science | 2 | 8% |
Other | 3 | 13% |
Unknown | 9 | 38% |