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Cardiac Gene Therapy

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Cover of 'Cardiac Gene Therapy'

Table of Contents

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    Book Overview
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    Chapter 1 Current Methods in Cardiac Gene Therapy: Overview.
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    Chapter 2 Silencing Genes in the Heart.
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    Chapter 3 Generation of Efficient miRNA Inhibitors Using Tough Decoy Constructs.
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    Chapter 4 Cardiac Gene Therapy
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    Chapter 5 Direct Cardiac Reprogramming as a Novel Therapeutic Strategy for Treatment of Myocardial Infarction.
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    Chapter 6 Production and Characterization of Vectors Based on the Cardiotropic AAV Serotype 9.
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    Chapter 7 Cell-Based Measurement of Neutralizing Antibodies Against Adeno-Associated Virus (AAV).
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    Chapter 8 Synthesis of Modified mRNA for Myocardial Delivery.
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    Chapter 9 Exosomes-Based Gene Therapy for MicroRNA Delivery.
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    Chapter 10 Lipidoid mRNA Nanoparticles for Myocardial Delivery in Rodents.
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    Chapter 11 Gene Transfer in Isolated Adult Cardiomyocytes.
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    Chapter 12 Gene Transfer in Cardiomyocytes Derived from ES and iPS Cells.
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    Chapter 13 Gene Transfer to Rodent Hearts In Vivo.
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    Chapter 14 Ultrasound-Targeted Microbubble Destruction for Cardiac Gene Delivery.
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    Chapter 15 A Needleless Liquid Jet Injection Delivery Approach for Cardiac Gene Therapy.
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    Chapter 16 Cardiac Gene Delivery in Large Animal Models: Antegrade Techniques.
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    Chapter 17 Direct Myocardial Injection of Vectors.
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    Chapter 18 Selective Pressure-Regulated Retroinfusion for Gene Therapy Application in Ischemic Heart Disease.
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    Chapter 19 Cardiac Gene Delivery Using Recirculating Devices.
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    Chapter 20 Molecular Cardiac Surgery with Recirculating Delivery (MCARD): Procedure and Vector Transfer.
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    Chapter 21 Gene Delivery for the Generation of Bioartificial Pacemaker.
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    Chapter 22 Gene Therapy for Post-infarction Ventricular Tachycardia.
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    Chapter 23 MicroRNA Delivery Strategies to the Lung in a Model of Pulmonary Hypertension.
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    Chapter 24 Inhaled Gene Transfer for Pulmonary Circulation.
Attention for Chapter 13: Gene Transfer to Rodent Hearts In Vivo.
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Chapter title
Gene Transfer to Rodent Hearts In Vivo.
Chapter number 13
Book title
Cardiac Gene Therapy
Published in
Methods in molecular biology, January 2017
DOI 10.1007/978-1-4939-6588-5_13
Pubmed ID
Book ISBNs
978-1-4939-6586-1, 978-1-4939-6588-5
Authors

Federica del Monte, Kiyotake Ishikawa, Roger J. Hajjar M.D., Roger J. Hajjar

Editors

Kiyotake Ishikawa

Abstract

Altering expression of specific genes in rodent models allows the dissection of various pathways involved in various disease states. Advances in gene transfer technologies produced vectors with tissue specificity, various time courses, increasing or knocking down genes in an externally controlled fashion. To achieve this goal, appropriate vector delivery method is essential for successfully conducting experiments. In this chapter, we focus on cardiac gene transfer in rodents that can be employed for delivering both viral and nonviral vectors.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 14%
Unknown 6 86%

Demographic breakdown

Readers by professional status Count As %
Professor > Associate Professor 2 29%
Other 1 14%
Unknown 4 57%
Readers by discipline Count As %
Medicine and Dentistry 3 43%
Unknown 4 57%