| Chapter title |
Immunosuppression in Lung Transplantation.
|
|---|---|
| Chapter number | 548 |
| Book title |
Pharmacology of Immunosuppression
|
| Published in |
Handbook of experimental pharmacology, November 2021
|
| DOI | 10.1007/164_2021_548 |
| Pubmed ID | |
| Book ISBNs |
978-3-03-105117-3, 978-3-03-105118-0
|
| Authors |
Nelson, Joelle, Kincaide, Elisabeth, Schulte, Jamie, Hall, Reed, Levine, Deborah Jo |
| Abstract |
Immunosuppression in lung transplantation is an area devoid of robust clinical data. This chapter will review the history of immunosuppression in lung transplantation. Additionally, it will evaluate the three classes of induction, maintenance, and rescue immunosuppression in detail. Induction immunosuppression in lung transplantation aims to decrease incidence of lung allograft rejection, however infectious risk must be considered when determining if induction is appropriate and which agent is most favorable. Similar to other solid organ transplant patient populations, a multi-drug approach is commonly prescribed for maintenance immunosuppression to minimize single agent drug toxicities. Emphasis of this review is placed on key medication considerations including dosing, adverse effects, and drug interactions. Clinical considerations will be reviewed per drug class given available literature. Finally, acute cellular, antibody mediated, and chronic rejection are reviewed. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Peru | 1 | 10% |
| Spain | 1 | 10% |
| Chile | 1 | 10% |
| Unknown | 7 | 70% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 5 | 50% |
| Members of the public | 5 | 50% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 4% |
| Unknown | 22 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 3 | 13% |
| Student > Master | 3 | 13% |
| Student > Postgraduate | 2 | 9% |
| Student > Bachelor | 1 | 4% |
| Professor | 1 | 4% |
| Other | 4 | 17% |
| Unknown | 9 | 39% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 7 | 30% |
| Biochemistry, Genetics and Molecular Biology | 2 | 9% |
| Psychology | 2 | 9% |
| Immunology and Microbiology | 1 | 4% |
| Business, Management and Accounting | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 9 | 39% |