Great work by Qin and coworkers showing in vivo prime editing in the Pde6b mouse model of retinitis pigmentosa using PE-SpRY. This was one of the first mutations we worked on in 2020/21, finding also low editing with PE-SpCas9. https://t.co/3ce8F4l5QR ht
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Here, as a proof-of-concept study, we describe a methodology using prime editing for the in vitro installation and correction of the classical Pde6brd10 c.1678C > T (p.Arg560Cys) mutation that causes autosomal recessive retinitis pigmentosa (RP) in mice
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Prime Editing for the Installation and Correction of Mutations Causing Inherited Retinal Disease: A Brief Methodology. https://t.co/3ce8F4lDGp
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Very happy to see mine and Dr. Tsang's co-edited methods book online at last! I also have three last authored chapters on Prime Editing (Pde6b), AAV Gene Delivery, and Retinal Organoids! Congrats to my current and former colleagues! https://t.co/3ce8F4lDG