Anhedonia: Preclinical, Translational, and Clinical Integration

Harkness, Kate L, Lamontagne, Steven J, Cunningham, Simone, Harkness, Kate L., Lamontagne, Steven J.

Anhedonia is a core feature of psychopathological conditions that have recent exposure to stress and trauma as central to their etiology. Indeed, evolutionary accounts of depression suggest that decreased motivation to pursue reward may be an adaptive strategy in the face of social stress, in particular, as it may serve to defuse interpersonal conflict. Through a review of rodent models and research with humans, we show that exposure to stress, particularly when it is chronic, repeated, and/or involves themes of social rejection or defeat, is consistently associated with reduced hedonic capacity ("liking"), motivation to pursue reward ("wanting"), and ability to learn from reward ("reward learning"). Further, across rodent and human research, there is evidence that females show greater stress-induced blunting of reward processing than males. In humans, this sex difference emerges most strongly when examining individual differences in the stress response rather than group differences in stress exposure. We discuss the implications of these findings for understanding the etiology of, and sex differences in, stress-related psychopathology, including depression and addiction.