| Chapter title |
Obesity and Obstructive Sleep Apnea
|
|---|---|
| Chapter number | 558 |
| Book title |
From Obesity to Diabetes
|
| Published in |
Handbook of experimental pharmacology, October 2021
|
| DOI | 10.1007/164_2021_558 |
| Pubmed ID | |
| Book ISBNs |
978-3-03-099994-0, 978-3-03-099995-7
|
| Authors |
Bonsignore, Maria R, Bonsignore, Maria R. |
| Abstract |
Obstructive sleep apnea (OSA) is characterized by upper airway collapse during sleep. Chronic intermittent hypoxia, sleep fragmentation, and inflammatory activation are the main pathophysiological mechanisms of OSA. OSA is highly prevalent in obese patients and may contribute to cardiometabolic risk by exerting detrimental effects on adipose tissue metabolism and potentiating the adipose tissue dysfunction typically found in obesity. This chapter will provide an update on: (a) the epidemiological studies linking obesity and OSA; (b) the studies exploring the effects of intermittent hypoxia and sleep fragmentation on the adipose tissue; (c) the effects of OSA treatment with continuous positive airway pressure (CPAP) on metabolic derangements; and (d) current research on new anti-diabetic drugs that could be useful in the treatment of obese OSA patients. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 6 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 2% |
| Germany | 1 | 2% |
| Unknown | 57 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 10 | 17% |
| Student > Bachelor | 8 | 14% |
| Other | 5 | 8% |
| Researcher | 5 | 8% |
| Student > Postgraduate | 4 | 7% |
| Other | 5 | 8% |
| Unknown | 22 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 20 | 34% |
| Nursing and Health Professions | 3 | 5% |
| Agricultural and Biological Sciences | 3 | 5% |
| Immunology and Microbiology | 3 | 5% |
| Biochemistry, Genetics and Molecular Biology | 2 | 3% |
| Other | 3 | 5% |
| Unknown | 25 | 42% |