Chapter title |
The Endocannabinoid System in Caenorhabditis elegans
|
---|---|
Chapter number | 64 |
Book title |
Reviews of Physiology, Biochemistry and Pharmacology
|
Published in |
Reviews of Physiology, Biochemistry and Pharmacology, January 2021
|
DOI | 10.1007/112_2021_64 |
Pubmed ID | |
Book ISBNs |
978-3-03-124203-8, 978-3-03-124204-5
|
Authors |
Estrada-Valencia, Rubén, Lima, María Eduarda de, Colonnello, Aline, Rangel-López, Edgar, Saraiva, Nariani Rocha, Ávila, Daiana Silva de, Aschner, Michael, Santamaría, Abel, de Lima, María Eduarda, de Ávila, Daiana Silva, Rubén Estrada-Valencia, María Eduarda de Lima, Aline Colonnello, Edgar Rangel-López, Nariani Rocha Saraiva, Daiana Silva de Ávila, Michael Aschner, Abel Santamaría |
Abstract |
The existence of a formal Endocannabinoid System in C. elegans has been questioned due to data showing the absence of typical cannabinoid receptors in the worm; however, the presence of a full metabolism for endocannabinoids, alternative ligands, and receptors for these agents and a considerable number of orthologous and homologous genes regulating physiological cannabinoid-like signals and responses - several of which are similar to those of mammals - demonstrates a well-structured and functional complex system in nematodes. In this review, we describe and compare similarities and differences between the Endocannabinoid System in mammals and nematodes, highlighting the basis for the integral study of this novel system in the worm. |
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