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Axon Regeneration

Overview of attention for book
Cover of 'Axon Regeneration'

Table of Contents

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    Book Overview
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    Chapter 7 Epigenomic Profiling of Dorsal Root Ganglia upon Regenerative and Non-regenerative Axonal Injury.
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    Chapter 15 Rapid Testing of Gene Function in Axonal Regeneration After Spinal Cord Injury Using Larval Zebrafish
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    Chapter 16 Translating Ribosome Affinity Purification (TRAP) and Bioinformatic RNA-Seq Analysis in Post-metamorphic Xenopus laevis.
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    Chapter 18 Profiling Dynamic Changes in DNA Accessibility During Axon Regeneration After Optic Nerve Crush in Adult Zebrafish.
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    Chapter 22 Drosophila Laser Axotomy Injury Model to Investigate RNA Repair and Splicing in Axon Regeneration
Attention for Chapter: Surgical Methods in Postmetamorphic Xenopus laevis: Optic Nerve Crush Injury Model.
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Chapter title
Surgical Methods in Postmetamorphic Xenopus laevis: Optic Nerve Crush Injury Model.
Book title
Axon Regeneration
Published in
Methods in molecular biology, January 2023
DOI 10.1007/978-1-0716-3012-9_11
Pubmed ID
36881302
Book ISBNs
978-1-07-163011-2, 978-1-07-163012-9
Authors

Feidler, Alexis M, Nguyen, Hieu H M, Watson, Fiona L, Feidler, Alexis M., Nguyen, Hieu H. M., Watson, Fiona L.

Abstract

Many human optic neuropathies lead to crippling conditions resulting in partial or complete loss of vision. While the retina is made up of several different cell types, retinal ganglion cells (RGCs) are the only cell type connecting the eye to the brain. Optic nerve crush injuries, wherein RGC axons are damaged without severing the optic nerve sheath, can serve as a model for traumatic optical neuropathies as well as some progressive neuropathies such as glaucoma. In this chapter, we describe two different surgical methods for establishing an optic nerve crush (ONC) injury in the postmetamorphic frog, Xenopus laevis. Why use the frog as an animal model? Mammals lose the ability to regenerate damaged CNS neurons, but amphibians and fish retain the ability to regenerate new RGC bodies and regrow RGC axons following an injury. In addition to presenting two different surgical ONC injury methods, we highlight their advantages and disadvantages and discuss the distinctive characteristics of Xenopus laevis as an animal model for studying CNS regeneration.

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 Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 April 2023.
All research outputs
#15,810,999
of 24,089,711 outputs
Outputs from Methods in molecular biology
#5,029
of 13,600 outputs
Outputs of similar age
#230,841
of 441,931 outputs
Outputs of similar age from Methods in molecular biology
#197
of 635 outputs
Altmetric has tracked 24,089,711 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,600 research outputs from this source. They receive a mean Attention Score of 3.5. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 441,931 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 635 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.

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