Title |
Biomimetic one-pot synthesis of gold nanoclusters/nanoparticles for targeted tumor cellular dual-modality imaging
|
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Published in |
Discover Nano, April 2013
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DOI | 10.1186/1556-276x-8-170 |
Pubmed ID | |
Authors |
Jing Lin, Zhijun Zhou, Zhiming Li, Chunlei Zhang, Xiansong Wang, Kan Wang, Guo Gao, Peng Huang, Daxiang Cui |
Abstract |
Biomimetic synthesis has become a promising green pathway to prepare nanomaterials. In this study, bovine serum albumin (BSA)-conjugated gold nanoclusters/nanoparticles were successfully synthesized in water at room temperature by a protein-directed, solution-phase, green synthetic method. The synthesized BSA-Au nanocomplexes have fluorescence emission (588 nm) of gold nanoclusters and surface plasmon resonance of gold nanoparticles. The BSA-Au nanocomplexes display non-cytotoxicity and excellent biocompatibility on MGC803 gastric cancer cells. After conjugation of folic acid molecules, the obtained BSA-Au nanocomplexes showed highly selective targeting for MGC803 cells and dual-modality dark-field and fluorescence imaging. |
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