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DNA Methyltransferases - Role and Function

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Cover of 'DNA Methyltransferases - Role and Function'

Table of Contents

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    Book Overview
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    Chapter 1 Mechanisms and Biological Roles of DNA Methyltransferases and DNA Methylation: From Past Achievements to Future Challenges.
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    Chapter 2 DNA and RNA Pyrimidine Nucleobase Alkylation at the Carbon-5 Position.
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    Chapter 3 Bacterial DNA Methylation and Methylomes.
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    Chapter 4 Domain Structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA Methyltransferases.
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    Chapter 5 Enzymology of Mammalian DNA Methyltransferases.
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    Chapter 6 Genetic Studies on Mammalian DNA Methyltransferases.
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    Chapter 7 The Role of DNA Methylation in Cancer.
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    Chapter 8 DNA Methyltransferases - Role and Function
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    Chapter 9 DNA Methyltransferases - Role and Function
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    Chapter 10 N6-Methyladenine: A Conserved and Dynamic DNA Mark.
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    Chapter 11 Pathways of DNA Demethylation.
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    Chapter 12 Structure and Function of TET Enzymes.
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    Chapter 13 Proteins That Read DNA Methylation.
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    Chapter 14 DNA Methyltransferases - Role and Function
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    Chapter 15 DNA Methyltransferases - Role and Function
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    Chapter 16 DNA Methyltransferase Inhibitors: Development and Applications.
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    Chapter 17 DNA Methyltransferases - Role and Function
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    Chapter 18 Engineering and Directed Evolution of DNA Methyltransferases.
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    Chapter 19 DNA Labeling Using DNA Methyltransferases.
Attention for Chapter 16: DNA Methyltransferase Inhibitors: Development and Applications.
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Summary
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Chapter title
DNA Methyltransferase Inhibitors: Development and Applications.
Chapter number 16
Book title
DNA Methyltransferases - Role and Function
Published in
Advances in experimental medicine and biology, November 2016
DOI 10.1007/978-3-319-43624-1_16
Pubmed ID
27826847
Book ISBNs
978-3-31-943622-7, 978-3-31-943624-1
Authors

Marie Lopez, Ludovic Halby, Paola B. Arimondo

Editors

Albert Jeltsch, Renata Z. Jurkowska

Abstract

As described in previous chapters of this book, DNA methylation is involved in numerous biological processes, and modulation of the activity of DNA methyltransferases (DNMTs) is a powerful strategy to modulate, restore, or reduce DNA methylation. In this chapter, we will present examples of inhibitors of DNMTs (DNMTi) and review the fields of applications of DNMTi mainly as therapeutic molecules, for example, in cancers, cardiovascular or neurological diseases, but also as bioengineering tools. Finally, the limits of currently available inhibitors will be discussed and the perspectives to discover improved DNMTi will be presented.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 82 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 13 16%
Researcher 12 15%
Student > Master 11 13%
Student > Ph. D. Student 10 12%
Student > Doctoral Student 5 6%
Other 12 15%
Unknown 19 23%
Readers by discipline Count As %
Medicine and Dentistry 18 22%
Biochemistry, Genetics and Molecular Biology 10 12%
Chemistry 9 11%
Agricultural and Biological Sciences 6 7%
Psychology 5 6%
Other 14 17%
Unknown 20 24%

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