Chapter title |
Bioinformatics for RNomics.
|
---|---|
Chapter number | 14 |
Book title |
Bioinformatics for Omics Data
|
Published in |
Methods in molecular biology, January 2011
|
DOI | 10.1007/978-1-61779-027-0_14 |
Pubmed ID | |
Book ISBNs |
978-1-61779-026-3, 978-1-61779-027-0
|
Authors |
Kristin Reiche, Katharina Schutt, Kerstin Boll, Friedemann Horn, Jörg Hackermüller, Reiche, Kristin, Schutt, Katharina, Boll, Kerstin, Horn, Friedemann, Hackermüller, Jörg |
Editors |
Bernd Mayer |
Abstract |
Rapid improvements in high-throughput experimental technologies make it nowadays possible to study the expression, as well as changes in expression, of whole transcriptomes under different environmental conditions in a detailed view. We describe current approaches to identify genome-wide functional RNA transcripts (experimentally as well as computationally), and focus on computational methods that may be utilized to disclose their function. While genome databases offer a wealth of information about known and putative functions for protein-coding genes, functional information for novel non-coding RNA genes is almost nonexistent. This is mainly explained by the lack of established software tools to efficiently reveal the function and evolutionary origin of non-coding RNA genes. Here, we describe in detail computational approaches one may follow to annotate and classify an RNA transcript. |
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