Title |
Systematic safety evaluation on photoluminescent carbon dots
|
---|---|
Published in |
Discover Nano, March 2013
|
DOI | 10.1186/1556-276x-8-122 |
Pubmed ID | |
Authors |
Kan Wang, Zhongcai Gao, Guo Gao, Yan Wo, Yuxia Wang, Guangxia Shen, Daxiang Cui |
Abstract |
Photoluminescent carbon dots (C-dots) were prepared using the improved nitric acid oxidation method. The C-dots were characterized by tapping-mode atomic force microscopy, and UV-vis absorption spectroscopy. The C-dots were subjected to systematic safety evaluation via acute toxicity, subacute toxicity, and genotoxicity experiments (including mouse bone marrow micronuclear test and Salmonella typhimurium mutagenicity test). The results showed that the C-dots were successfully prepared with good stability, high dispersibility, and water solubility. At all studied C-dot dosages, no significant toxic effect, i.e., no abnormality or lesion, was observed in the organs of the animals. Therefore, the C-dots are non-toxic to mice under any dose and have potential use in fluorescence imaging in vivo, tumor cell tracking, and others. |
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Geographical breakdown
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India | 1 | <1% |
China | 1 | <1% |
Slovenia | 1 | <1% |
Unknown | 181 | 98% |
Demographic breakdown
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Researcher | 35 | 19% |
Student > Bachelor | 18 | 10% |
Student > Master | 14 | 8% |
Professor > Associate Professor | 9 | 5% |
Other | 22 | 12% |
Unknown | 43 | 23% |
Readers by discipline | Count | As % |
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Materials Science | 17 | 9% |
Engineering | 13 | 7% |
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Biochemistry, Genetics and Molecular Biology | 9 | 5% |
Other | 30 | 16% |
Unknown | 59 | 32% |