Chapter title |
Delta Opioid Pharmacology in Parkinson’s Disease
|
---|---|
Chapter number | 16 |
Book title |
Delta Opioid Receptor Pharmacology and Therapeutic Applications
|
Published in |
Handbook of experimental pharmacology, October 2016
|
DOI | 10.1007/164_2016_16 |
Pubmed ID | |
Book ISBNs |
978-3-31-995131-7, 978-3-31-995133-1
|
Authors |
Mabrouk, Omar S, Omar S. Mabrouk, Mabrouk, Omar S. |
Abstract |
Parkinson's disease (PD) is a progressive neurodegenerative disorder that compromises multiple neurochemical substrates including dopamine, norepinephrine, serotonin, acetylcholine, and glutamate systems. Loss of these transmitter systems initiates a cascade of neurological deficits beginning with motor function and ending with dementia. Current therapies primarily address the motor symptoms of the disease via dopamine replacement therapy. Exogenous dopamine replacement brings about additional challenges since after years of treatment it almost invariably gives rise to dyskinesia as a side effect. Therefore there is a clear unmet clinical need for improved PD therapeutics. Opioid receptors and their respective peptides are expressed throughout the basal ganglia and cortex where monoaminergic denervation strongly contributes to PD pathology. Delta opioid receptors are of particular interest because of their dense localization in basal ganglia and because activating this system is known to enhance locomotor activity under a variety of conditions. This chapter will outline much of the work that has demonstrated the effectiveness of delta opioid receptor activation in models of PD and its neuroprotective properties. It also discusses some of the challenges that must be addressed before moving delta opioid receptor agonists into a clinical setting. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 5 | 33% |
Other | 2 | 13% |
Student > Master | 2 | 13% |
Student > Ph. D. Student | 1 | 7% |
Lecturer | 1 | 7% |
Other | 0 | 0% |
Unknown | 4 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 3 | 20% |
Psychology | 2 | 13% |
Biochemistry, Genetics and Molecular Biology | 1 | 7% |
Nursing and Health Professions | 1 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 7% |
Other | 3 | 20% |
Unknown | 4 | 27% |