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Timeline
Mendeley readers
Chapter title |
Validation of Computational Methods.
|
---|---|
Chapter number | 6 |
Book title |
Validation of Alternative Methods for Toxicity Testing
|
Published in |
Advances in experimental medicine and biology, September 2016
|
DOI | 10.1007/978-3-319-33826-2_6 |
Pubmed ID | |
Book ISBNs |
978-3-31-933824-8, 978-3-31-933826-2
|
Authors |
Grace Patlewicz, Andrew P. Worth, Nicholas Ball |
Editors |
Chantra Eskes, Maurice Whelan |
Abstract |
In this chapter, we provide an overview of how (Quantitative) Structure Activity Relationships, (Q)SARs, are validated and applied for regulatory purposes. We outline how chemical categories are derived to facilitate endpoint specific read-across using tools such as the OECD QSAR Toolbox and discuss some of the current difficulties in addressing the residual uncertainties of read-across. Finally we put forward a perspective of how non-testing approaches may evolve in light of the advances in new and emerging technologies and how these fit within the Adverse Outcome Pathway (AOP) framework. |
Mendeley readers
The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Bulgaria | 1 | 4% |
Unknown | 24 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 4 | 16% |
Student > Doctoral Student | 4 | 16% |
Researcher | 3 | 12% |
Unspecified | 2 | 8% |
Professor | 1 | 4% |
Other | 1 | 4% |
Unknown | 10 | 40% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 4 | 16% |
Unspecified | 2 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 8% |
Computer Science | 2 | 8% |
Environmental Science | 1 | 4% |
Other | 4 | 16% |
Unknown | 10 | 40% |