| Chapter title |
Using phage as a platform to select cancer cell-targeting peptides.
|
|---|---|
| Chapter number | 4 |
| Book title |
Virus Hybrids as Nanomaterials
|
| Published in |
Methods in molecular biology, October 2013
|
| DOI | 10.1007/978-1-62703-751-8_4 |
| Pubmed ID | |
| Book ISBNs |
978-1-62703-750-1, 978-1-62703-751-8
|
| Authors |
Xin Li, Chuanbin Mao, Li, Xin, Mao, Chuanbin |
| Editors |
Baochuan Lin, Banahalli Ratna |
| Abstract |
One challenge in the development of cancer therapies is the availability of cancer-specific ligands. Recently, phage-displayed peptide libraries have been used for the selection of peptide-based cell-targeting ligands, especially cancer cell ligands. Here we describe the methods to identify SKBR-3 breast cancer cell-specific peptides from a phage-displayed random peptide library. It is possible to select both cell-surface-binding and cell-internalizing peptides using this method. This method can also be applied to the selection of targeting peptides for other adherent cancer cells. The identified short peptides can be potentially incorporated into a variety of early diagnostic and targeted therapeutic systems against breast cancer. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 4% |
| Denmark | 1 | 4% |
| Unknown | 21 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 22% |
| Student > Master | 5 | 22% |
| Professor | 3 | 13% |
| Student > Postgraduate | 2 | 9% |
| Other | 1 | 4% |
| Other | 3 | 13% |
| Unknown | 4 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 9 | 39% |
| Agricultural and Biological Sciences | 5 | 22% |
| Veterinary Science and Veterinary Medicine | 1 | 4% |
| Medicine and Dentistry | 1 | 4% |
| Chemistry | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 6 | 26% |