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Proteogenomics

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Attention for Chapter 10: Proteogenomics for the Comprehensive Analysis of Human Cellular and Serum Antibody Repertoires.
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Chapter title
Proteogenomics for the Comprehensive Analysis of Human Cellular and Serum Antibody Repertoires.
Chapter number 10
Book title
Proteogenomics
Published in
Advances in experimental medicine and biology, September 2016
DOI 10.1007/978-3-319-42316-6_10
Pubmed ID
Book ISBNs
978-3-31-942314-2, 978-3-31-942316-6
Authors

Paula Díez, Manuel Fuentes

Editors

Ákos Végvári

Abstract

The vast repertoire of immunoglobulins produced by the immune system is a consequence of the huge amount of antigens to which we are exposed every day. The diversity of these immunoglobulins is due to different mechanisms (including VDJ recombination, somatic hypermutation, and antigen selection). Understanding how the immune system is capable of generating this diversity and which are the molecular bases of the composition of immunoglobulins are key challenges in the immunological field. During the last decades, several techniques have emerged as promising strategies to achieve these goals, but it is their combination which appears to be the fruitful solution for increasing the knowledge about human cellular and serum antibody repertoires.In this chapter, we address the diverse strategies focused on the analysis of immunoglobulin repertoires as well as the characterization of the genomic and peptide sequences. Moreover, the advantages of combining various -omics approaches are discussed through review different published studies, showing the benefits in clinical areas.

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Mendeley readers

Mendeley readers

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Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 30%
Professor 2 20%
Student > Doctoral Student 2 20%
Student > Master 1 10%
Researcher 1 10%
Other 0 0%
Unknown 1 10%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 30%
Medicine and Dentistry 2 20%
Pharmacology, Toxicology and Pharmaceutical Science 1 10%
Arts and Humanities 1 10%
Agricultural and Biological Sciences 1 10%
Other 1 10%
Unknown 1 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 June 2017.
All research outputs
#20,344,065
of 22,890,496 outputs
Outputs from Advances in experimental medicine and biology
#3,973
of 4,952 outputs
Outputs of similar age
#279,615
of 322,482 outputs
Outputs of similar age from Advances in experimental medicine and biology
#97
of 119 outputs
Altmetric has tracked 22,890,496 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,952 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 119 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.