Chapter title |
Using Proteomics Bioinformatics Tools and Resources in Proteogenomic Studies.
|
---|---|
Chapter number | 5 |
Book title |
Proteogenomics
|
Published in |
Advances in experimental medicine and biology, September 2016
|
DOI | 10.1007/978-3-319-42316-6_5 |
Pubmed ID | |
Book ISBNs |
978-3-31-942314-2, 978-3-31-942316-6
|
Authors |
Marc Vaudel, Harald Barsnes, Helge Ræder, Frode S. Berven |
Editors |
Ákos Végvári |
Abstract |
Proteogenomic studies ally the omic fields related to gene expression into a combined approach to improve the characterization of biological samples. Part of this consists in mining proteomics datasets for non-canonical sequences of amino acids. These include intergenic peptides, products of mutations, or of RNA editing events hypothesized from genomic, epigenomic, or transcriptomic data. This approach poses new challenges for standard peptide identification workflows. In this chapter, we present the principles behind the use of peptide identification algorithms and highlight the major pitfalls of their application to proteogenomic studies. |
X Demographics
Geographical breakdown
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United States | 2 | 67% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 6% |
Unknown | 17 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 3 | 17% |
Student > Ph. D. Student | 2 | 11% |
Researcher | 2 | 11% |
Student > Master | 2 | 11% |
Student > Bachelor | 1 | 6% |
Other | 4 | 22% |
Unknown | 4 | 22% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 7 | 39% |
Agricultural and Biological Sciences | 4 | 22% |
Computer Science | 3 | 17% |
Unknown | 4 | 22% |