Chapter title |
WNT Signalling in Osteoarthritis and Its Pharmacological Targeting.
|
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Book title |
Pharmacology of the WNT Signaling System
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Published in |
Handbook of experimental pharmacology, September 2021
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DOI | 10.1007/164_2021_525 |
Pubmed ID | |
Book ISBNs |
978-3-03-085498-0, 978-3-03-085499-7
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Authors |
De Palma, Anna, Nalesso, Giovanna, Palma, Anna De |
Abstract |
Osteoarthritis (OA) is a highly disabling musculoskeletal condition affecting millions of people worldwide. OA is characterised by progressive destruction and irreversible morphological changes of joint tissues and architecture. At molecular level, de-regulation of several pathways contributes to the disruption of tissue homeostasis in the joint. Overactivation of the WNT/β-catenin signalling pathway has been associated with degenerative processes in OA. However, the multiple layers of complexity in the modulation of the signalling and the still insufficient knowledge of the specific molecular drivers of pathogenetic mechanisms have made difficult the pharmacological targeting of this pathway for therapeutic purposes. This review aims to provide an overview of the WNT/β-catenin signalling in OA with a particular focus on its role in the articular cartilage. Pathway components whose targeting showed therapeutic potential will be highlighted and described. A specific section will be dedicated to Lorecivivint, the first inhibitor of the β-catenin-dependent pathway currently in phase III clinical trial as OA-modifying agent. |
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Members of the public | 1 | 100% |
Mendeley readers
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Unknown | 8 | 100% |
Demographic breakdown
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Student > Ph. D. Student | 2 | 25% |
Researcher | 1 | 13% |
Lecturer | 1 | 13% |
Unknown | 4 | 50% |
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Biochemistry, Genetics and Molecular Biology | 2 | 25% |
Immunology and Microbiology | 1 | 13% |
Medicine and Dentistry | 1 | 13% |
Engineering | 1 | 13% |
Unknown | 3 | 38% |